2-(2-oxo-2-(piperidin-1-yl)ethyl)benzonitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-oxo-2-(piperidin-1-yl)ethyl)benzonitrile
• 英文别名: 2-(2-Oxo-2-piperidin-1-ylethyl)benzonitrile；2-(2-oxo-2-piperidin-1-ylethyl)benzonitrile
• 化学式: C₁₄H₁₆N₂O
• 分子量: 228.294
• InChiKey: IWFQNZFSLCCCPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(2-oxo-2-(piperidin-1-yl)ethyl)benzonitrile 在 air 、 四丁基溴化铵 、 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 8.5h， 以50%的产率得到邻苯二甲酸亚胺
  参考文献：
  名称：

  Cesium carbonate promoted aerobic oxidation of arylacetamides: an efficient access to N-substituted α-keto amides

  摘要：

  A novel cesium carbonate promoted aerobic oxidation reaction to prepare N-substituted alpha-keto amides in the presence of catalytic amount of tetra-n-butylammonium bromide was described. This reaction provides a very simple and convenient route from easily available arylacetamides in good to high yields. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.10.099
• 作为产物：
  描述：

  哌啶 、 1,1-二溴-2-(邻氰基苯基)乙烯 在 氢氧化钾 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 15.0h， 以90%的产率得到2-(2-oxo-2-(piperidin-1-yl)ethyl)benzonitrile
  参考文献：
  名称：

  Cesium carbonate promoted aerobic oxidation of arylacetamides: an efficient access to N-substituted α-keto amides

  摘要：

  A novel cesium carbonate promoted aerobic oxidation reaction to prepare N-substituted alpha-keto amides in the presence of catalytic amount of tetra-n-butylammonium bromide was described. This reaction provides a very simple and convenient route from easily available arylacetamides in good to high yields. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.10.099

文献信息

• Cesium carbonate promoted aerobic oxidation of arylacetamides: an efficient access to N-substituted α-keto amides
  作者：Bingrui Song、Siyuan Wang、Caiyun Sun、Hongmei Deng、Bin Xu

  DOI：10.1016/j.tetlet.2007.10.099

  日期：2007.12

  A novel cesium carbonate promoted aerobic oxidation reaction to prepare N-substituted alpha-keto amides in the presence of catalytic amount of tetra-n-butylammonium bromide was described. This reaction provides a very simple and convenient route from easily available arylacetamides in good to high yields. (c) 2007 Elsevier Ltd. All rights reserved.