全氟代十四酸 | 376-06-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 全氟代十四酸
• 中文别名: 全氟十四酸
• 英文名称: perfluorotetradecanoic acid
• 英文别名: PFTeDA；PFTA；2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,13,13,14,14,14-heptacosafluorotetradecanoic acid
• CAS: 376-06-7
• 化学式: C₁₄HF₂₇O₂
• 分子量: 714.118
• InChiKey: RUDINRUXCKIXAJ-UHFFFAOYSA-N

物化性质

• 熔点：
  130-135 °C(lit.)
• 沸点：
  270 °C740 mm Hg(lit.)
• 密度：
  0.89
• 闪点：
  192°C/60mm
• 溶解度：
  可溶于氯仿（轻微、加热、超声处理）、甲醇（轻微、超声处理）

计算性质

• 辛醇/水分配系数(LogP)：
  9
• 重原子数：
  43
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  29

安全信息

• TSCA：
  Yes
• 危险等级：
  8
• 危险品标志：
  C
• 危险类别码：
  R34
• 危险品运输编号：
  3261
• WGK Germany：
  3
• 包装等级：
  II
• 危险类别：
  8
• 安全说明：
  S26,S36/37/39,S45
• 储存条件：
  室温

SDS

Name:	Perfluorotetradecanoic acid Material Safety Data Sheet
Synonym:	None
CAS:	376-06-7

Section 1 - Chemical Product MSDS Name:Perfluorotetradecanoic acid Material Safety Data Sheet
Synonym:None

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
376-06-7	Perfluorotetradecanoic acid	100	206-803-4

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Use with adequate ventilation.
Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 376-06-7: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: white to off-white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 270 deg C @ 740 mmHg
Freezing/Melting Point: 131-137 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: CF3(CF2)12CO2H
Molecular Weight: 714.12

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Dust generation, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, hydrogen fluoride gas, fluoride fumes.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 376-06-7 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
Perfluorotetradecanoic acid - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing group:

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
S 28A After contact with skin, wash immediately with
plenty of water.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 376-06-7: No information available.
Canada
CAS# 376-06-7 is listed on Canada's NDSL List.
CAS# 376-06-7 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 376-06-7 is listed on the TSCA inventory.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  全氟代十四酸 在 1,3-二碘-5,5-二甲基海因 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 24.0h， 以78%的产率得到perfluorotridecyl iodide
  参考文献：
  名称：

  具有可生物降解副产物的无金属高效，通用和简便的碘脱羧方法

  摘要：

  据报道，在不使用重金属或强氧化剂的情况下，将脂肪族和芳香族羧酸一般转化为有机碘化物的新颖，有效和鲁棒的方法的开发。在辐照条件下，可商购获得的N-碘酰胺既用于引发反应，又用于卤素的捐赠。产品的分离非常简单，主要副产物作为水溶性生物可降解材料被去除。

  DOI：

  10.1002/adsc.201100145
• 作为产物：
  描述：

  肉豆蔻酸酐 在 氢氟酸 作用下， 生成 全氟代十四酸
  参考文献：
  名称：

  全氟羧酸的一些性质

  摘要：

  DOI：

  10.1021/ie50502a044

文献信息

• [EN] PROCESS FOR THE PREPARATION OF IODIDES<br/>[FR] PROCÉDÉ DE PRÉPARATION D'IODURES
  申请人：TECHNION R & D FOUNDATION LTD

  公开号：WO2011154953A1

  公开（公告）日：2011-12-15

  This invention is directed to a process for the preparation of high yield alkyl or aryl iodide from its corresponding carboxylic acid using N-iodo amides.

  这项发明涉及利用N-碘酰胺从相应的羧酸制备高产量的烷基或芳基碘化物的过程。
• Method for producing carboxylic acid by alcohol oxidation
  申请人：——

  公开号：US20030045751A1

  公开（公告）日：2003-03-06

  The invention relates to a method for oxidizing primary amino alcohols, primary or secondary alkenols or alkinols into the corresponding acids or ketones. According to said method, a primary amino alcohol or a primary or secondary alkenol or alkinol is oxidized in the form of a substrate, in the presence of an equimolar quantity of periodate or a molar excess thereof in relation to the alcoholic hydroxy groups and catalytic quantities of dichromate or CrO 3 and in the presence of an acid in water, a water/solvent mixture or a solvent at a temperature of −20 ° C. to +50 ° C., to produce the corresponding acid or the corresponding ketone.

  该发明涉及一种将一级氨基醇、一级或二级烯醇或炔醇氧化为相应酸或酮的方法。根据该方法，在存在与醇羟基相对应的等摩尔量的高碘酸盐或其摩尔过量的情况下，将一级氨基醇或一级或二级烯醇或炔醇作为底物氧化，并在水中的酸、水/溶剂混合物或溶剂中，在温度为-20°C至+50°C的条件下，产生相应的酸或相应的酮。
• Perfluoroalkyl bile esters: a new class of efficient gelators of organic and aqueous–organic media
  作者：Supratim Banerjee、V. M. Vidya、A. J. Savyasachi、Uday Maitra

  DOI：10.1039/c1jm11912e

  日期：——

  A new class of fluorinated gelators derived from bile acids is reported. Perfluoroalkyl chains were attached to the bile acids through two different ester linkages and were synthesized following simple transformations. The gelation property of these derivatives is a function of the bile acid moiety, the spacer and the fluoroalkyl chain length. By varying these parameters, gels were obtained in aromatic hydrocarbons, DMSO and DMSO/DMF–H2O mixtures of different proportions. Several derivatives of deoxycholic and lithocholic acids were found to be efficient organogelators, while the reported bile-acid based organogelators are mostly derived from the cholic acid moiety. The efficient gelators among these compounds formed gels well below 1.0% (w/v) and hence they can be termed as supergelators. The mechanical properties of these gels could be modulated by changing either the bile acid moiety or by varying the length of the fluoroalkyl segment. The presence of CO2-philic perfluoroalkyl groups is also expected to enhance their solubility in supercritical CO2 and hence these compounds are promising candidates for making aerogels.

  报告了一类源自胆汁酸的新型氟化凝胶剂。全氟烷基链通过两种不同的酯键连接到胆汁酸，经过简单转化合成。这些衍生物的凝胶性能取决于胆汁酸部分、间隔链和氟烷基链的长度。通过改变这些参数，可以在芳香烃、DMSO以及不同比例的DMSO/DMF-H2O混合物中获得凝胶。发现几种脱氧胆酸和石胆酸的衍生物是高效的有机凝胶剂，而现有的基于胆汁酸的有机凝胶剂大多源于胆酸部分。这些化合物中高效的凝胶剂在低于1.0%（w/v）的浓度下即可形成凝胶，因此可以称之为超凝胶剂。通过改变胆汁酸部分或氟烷基段的长度，可以调节这些凝胶的机械性能。CO₂亲和的全氟烷基团的存在也预计将增强其在超临界CO₂中的溶解度，因此这些化合物在制作气凝胶方面具有很大的潜力。
• Iodinated polymers for biological agent defeat
  申请人：Department of the Navy

  公开号：US10342232B1

  公开（公告）日：2019-07-09

  A binder, and related processes, has been developed for biological agent defeat formulations. This highly iodinated binder is based on the polymer polyethylene tetraiodoterephthalamide. The materials have been formulated with metal fuel particles, such as aluminum, and various oxidizers, such as metal oxides. The binder-thermite composites may be actuated to initiate oxidation, therein generating heat. Upon thermal decomposition of these materials, iodine, a biocide, is released allowing for sterilization of biological agents.

  已开发出一种用于生物制剂的粘结剂及相关工艺。这种高碘化粘结剂基于聚合物聚乙烯四碘对苯二甲酰胺。这些材料已与金属燃料颗粒（如铝）和各种氧化剂（如金属氧化物）配制而成。粘结剂-热剂复合材料可以被激活以启动氧化反应，从而产生热量。在这些材料的热分解过程中，碘（一种生物杀菌剂）被释放出来，从而实现对生物制剂的灭菌。
• PROCESS FOR PRODUCING ESTER COMPOUND
  申请人：Imazeki Shigeaki

  公开号：US20100324314A1

  公开（公告）日：2010-12-23

  PROBLEM To provide an environmentally-friendly method for producing industrially an ester compound. SOLUTION The present invention is a method for producing an ester compound which comprises subjecting a carboxylic acid and an alcohol to dehydration-condensation reaction using an involatile acid catalyst and then removing the residual acid catalyst by bringing a weak basic substance into contact with the residual acid catalyst.

  问题提供一种生产工业酯化合物的环保方法。 解决方案是一种生产酯化合物的方法，包括将羧酸和醇经过脱水缩合反应，使用一种不挥发的酸催化剂，然后通过将弱碱性物质与残留的酸催化剂接触来去除残留的酸催化剂。