申请人:ISHIHARA SANGYO KAISHA, LTD.
公开号:US20030187264A1
公开(公告)日:2003-10-02
This invention relates to a method for producing compounds of the formula (I) or their salts:
1
wherein each of R
1
and R
2
is hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, OR
3
, SR
3
, COR
3
, COOR
3
or cyano;
R
1
and R
2
may combine together with the adjacent carbon atom of ═CR
1
R
2
to form an unsubstituted or substituted cyclic ring;
each of R
4
and R
5
is hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, NR
6
R
7
, OR
8
or SR
9
;
R
4
and R
5
may combine together with the adjacent skeleton of C/N bond to form a heterocyclic ring;
which comprises rearranging compounds of the formula (II) or their salts:
2
wherein R
1
, R
2
, R
4
and R
5
are as defined above.
本发明涉及一种制备式(I)化合物或其盐的方法:其中R1和R2中的每一个都是氢、未取代或取代的烷基、未取代或取代的烯基、未取代或取代的炔基、未取代或取代的芳基、未取代或取代的杂环芳基、OR3、SR3、COR3、COOR3或氰基;R1和R2可以与相邻的碳原子结合形成未取代或取代的环状环;R4和R5中的每一个都是氢、未取代或取代的烷基、未取代或取代的烯基、未取代或取代的炔基、未取代或取代的芳基、未取代或取代的杂环芳基、NR6R7、OR8或SR9;R4和R5可以与相邻的C/N键骨架结合形成杂环环;其包括重排式(II)化合物或其盐的方法:其中R1、R2、R4和R5如上所定义。