2-[(1E)-1-(1-benzoyl-1,2-dihydro-3H-indol-3-ylidene)ethyl]-1-methyl-1H-indole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-[(1E)-1-(1-benzoyl-1,2-dihydro-3H-indol-3-ylidene)ethyl]-1-methyl-1H-indole
• 英文别名: [(3E)-3-[1-(1-methylindol-2-yl)ethylidene]-2H-indol-1-yl]-phenylmethanone
• 化学式: C₂₆H₂₂N₂O
• 分子量: 378.473
• InChiKey: XLVUKXJWCRQMRZ-PYCFMQQDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  29
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  25.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-(2-iodophenyl)-N-(prop-2-yn-1-yl)benzamide 在 叔丁基锂 作用下， 反应 0.5h， 生成 2-[(1E)-1-(1-benzoyl-1,2-dihydro-3H-indol-3-ylidene)ethyl]-1-methyl-1H-indole
  参考文献：
  名称：

  A palladium-catalyzed tandem cyclization-cross-coupling reaction using indolylborate as a transfer agent

  摘要：

  Investigation of the palladium-catalyzed tandem cyclization-cross-coupling reaction using indolylborate (2) as a transfer agent has been carried out. Furthermore, the cross-coupling reaction performed under carbon monoxide led to the generation of indolyl ketones. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.09.065

文献信息

• Palladium-catalysed tandem cyclisation–cross-coupling reaction with triethyl-(1-methylindol-2-yl)borate
  作者：Minoru Ishikura

  DOI：10.1039/c39950000409

  日期：——

  Triethyl(1-methylindol-2-yl)borate 1 is successfully applied for the palladium-catalysed tandem cyclisation–cross-coupling reaction, which is used for a concise access to ellipticine derivatives.

  （1-甲基吲哚-2-基）硼酸三乙酯1已成功用于钯催化的串联环化-交叉偶联反应，该反应可用于简化玫瑰树碱衍生物的制备。
• A palladium-catalyzed tandem cyclization-cross-coupling reaction using indolylborate as a transfer agent
  作者：Minoru Ishikura、Norinobu Takahashi、Koji Yamada、Reiko Yanada

  DOI：10.1016/j.tet.2006.09.065

  日期：2006.12

  Investigation of the palladium-catalyzed tandem cyclization-cross-coupling reaction using indolylborate (2) as a transfer agent has been carried out. Furthermore, the cross-coupling reaction performed under carbon monoxide led to the generation of indolyl ketones. (c) 2006 Elsevier Ltd. All rights reserved.