1-(2-methoxyphenyl)pyridin-1-ium chloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2-methoxyphenyl)pyridin-1-ium chloride
• 英文别名: N-(o-methoxyphenyl)pyridinium chloride；1-(2-Methoxyphenyl)pyridin-1-ium;chloride
• 化学式: C₁₂H₁₂NO*Cl
• 分子量: 221.686
• InChiKey: MOAWZFPOPRSUQP-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.02
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  13.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  glutodialdehyde sodium salt 在 盐酸 作用下， 以 乙醇 为溶剂， 生成 1-(2-methoxyphenyl)pyridin-1-ium chloride
  参考文献：
  名称：

  Complex Salts of TCNQ with Substituted Phenyl Pyridines and Their Characterization by Scanning Tunneling Microscopy

  摘要：

  AbstractNew conductive complex salts of tetracyanoquinodimethane (TCNQ) with substituted phenylpyridines have been prepared and characterized by optical microscopy, conductivity measurements, X‐ray powder diagrams and scanning tunneling microscopy (STM). The molecular stacking, which is responsible for the one‐dimensional conductivity, was revealed from the diffraction data and STM images. The analysis of the STM images was based on the results obtained on a model compound, the complex salt of TCNQ and quinolinium. Although in STM the surface partial electron density is measured, several crystallographic parameters of the molecular arrangement have been determined from these images.

  DOI：

  10.1002/bbpc.19930971110

文献信息

• Microwaves and Aqueous Solvents Promote the Reaction of Poorly Nucleophilic Anilines with a Zincke Salt
  作者：Narimane Zeghbib、Paul Thelliere、Michael Rivard、Thierry Martens

  DOI：10.1021/acs.joc.6b00208

  日期：2016.4.15

  engaged in Zincke reactions. Efficient transformations were obtained, even when conducted on electronically deactivated, eventually also sterically hindered, substrates. This was achieved by the combined use of microwave activation and aqueous solvents. Under our conditions, the role of water revealed indeed crucial to avoid the self-degradation of the Zincke salt, the reagent of the reaction.

  Zincke反应可将伯胺转化为各自的N-烷基化或N-芳基吡啶鎓盐。虽然亲核伯胺（通常是脂肪族伯胺）通常会导致定量反应，并且已经有大量文献证明，但不良亲核胺的使用仍需要深入研究。迄今为止，胺的亲核性缺乏是重新抑制的。本文涉及的主题是一系列已参与Zincke反应的衍生自苯胺的伯胺。即使在电子失活的，最终也是空间受阻的底物上进行，也可以获得有效的转化。这是通过结合使用微波活化和水性溶剂来实现的。在我们的条件下，水的作用确实显示对于避免反应试剂辛克盐的自降解至关重要。