1,1-bis-thiazol-2-yl-ethanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1,1-bis-thiazol-2-yl-ethanol
• 英文别名: 1,1-di(2-thiazolyl)ethanol；Methyl-dithiazolyl-(2)-carbinol；1,1-bis(1,3-thiazol-2-yl)ethanol
• 化学式: C₈H₈N₂OS₂
• 分子量: 212.296
• InChiKey: MIAXBEYRCWGQNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  103
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-溴噻唑 、 乙酸-D1 生成 1,1-bis-thiazol-2-yl-ethanol
  参考文献：
  名称：

  Roussel,P.; Metzger,J., Bulletin de la Societe Chimique de France, 1962, p. 2075 - 2078

  摘要：

  DOI：

文献信息

• BENZIMIDAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS
  申请人：Gilead Sciences, Inc.

  公开号：US20140336190A1

  公开（公告）日：2014-11-13

  This application relates to chemical compounds which may act as inhibitors of; or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R 1a , R 1b , R 2 , R 2b , R 3 , R 4a , R 4b , and R 5 are described herein.

  这个应用涉及可能作为抑制剂的化合物；或者可能以其他方式调节溴结构域含蛋白的活性，包括溴结构域含蛋白4（BRD4），以及含有这些化合物的组合物和配方，以及使用和制备这些化合物的方法。化合物包括式（I）的化合物 其中R 1a ，R 1b ，R 2 ，R 2b ，R 3 ，R 4a ，R 4b 和R 5 如本文所述。
• 1,1-bis(heteroazolyl)alkane derivatives and their use as neuroprotective
  申请人：——

  公开号：US05665747A1

  公开（公告）日：1997-09-09

  The present invention relates to novel heterocyclic compounds having the general formula (1) ##STR1## wherein: X.sub.1 and X.sub.2 are independently O, S or Se; Y.sub.1 and Y.sub.2 are independently C or N with the proviso that at least one of Y.sub.1 and Y.sub.2 is N; Y.sub.3 and Y.sub.4 are independently C or N with the proviso that at least one of Y.sub.3 and Y.sub.4 is N; R.sub.1 and R.sub.2 each represent one or more groups independently selected from H, lower alkyl, lower alkoxy-lower alkyl, hydroxy-lower alkyl, lower acyloxy-lower alkyl or CF.sub.3 ; and A is ##STR2## geometrical and optical isomers and racemates thereof where such isomers exist, as well as pharmaceutically acceptable acid addition salts thereof and solvates thereof; having therapeutic activity, processes and intermediates for their preparation, pharmaceutical formulations containing said compounds and the medicinal use of said compounds.

  本发明涉及具有通式（1）的新型杂环化合物 其中：X₁和X₂分别独立地为O、S或Se；Y₁和Y₂分别独立地为C或N，但至少其中一个为N；Y₃和Y₄分别独立地为C或N，但至少其中一个为N；R₁和R₂分别代表一个或多个从H、较低烷基、较低烷氧基-较低烷基、羟基-较低烷基、较低酰氧基-较低烷基或CF₃中独立选择的基团；以及A为 它们的几何和光学异构体和盐酸盐以及溶剂化合物，其具有治疗活性，以及其制备的过程和中间体，含有所述化合物的药物配方和所述化合物的药用。
• 1, 1-BIS (heteroazolyl) alkane derivatives and their use as
  申请人：Astra Aktiebolag

  公开号：US05843971A1

  公开（公告）日：1998-12-01

  The present invention relates to novel heterocyclic compounds having the general formula (1) ##STR1## wherein: X.sub.1 and X.sub.2 are independently O, S or Se; Y.sub.1 and Y.sub.2 are independently C or N with the proviso that at least one of Y.sub.1 and Y.sub.2 is N; Y.sub.3 and Y.sub.4 are independently C or N with the proviso that at least one of Y.sub.3 and Y.sub.4 is N; R.sub.1 and R.sub.2 each represent one or more groups independently selected from H, lower alkyl, lower alkoxy-lower alkyl, hydroxy-lower alkyl, lower acyloxy-lower alkyl or CF.sub.3 ; and A is ##STR2## geometrical and optical isomers and racemates thereof where such isomers exist, as well as pharmaceutically acceptable acid addition salts thereof and solvates thereof; having therapeutic activity, processes and intermediates for their preparation, pharmaceutical formulations containing said compounds and the medicinal use of said compounds.

  本发明涉及具有一般式（1）的新型杂环化合物 其中：X1和X2独立地是O，S或Se；Y1和Y2独立地是C或N，但至少其中之一是N；Y3和Y4独立地是C或N，但至少其中之一是N；R1和R2分别表示H，较低的烷基，较低的烷氧基-较低的烷基，羟基-较低的烷基，较低的酰氧基-较低的烷基或CF3中的一个或多个基团；A是 其中，存在这样的异构体时，包括其几何和光学异构体和外消旋体，以及其药学上可接受的酸盐和溶剂化物；具有治疗活性，用于其制备的过程和中间体，含有所述化合物的制药组合物以及所述化合物的药用。
• NOVEL 1,1-BIS(HETEROAZOLYL)ALKANE DERIVATIVES AND THEIR USE AS NEUROPROTECTIVE AGENTS
  申请人：Astra Aktiebolag

  公开号：EP0765325A1

  公开（公告）日：1997-04-02
• US5665747A
  申请人：——

  公开号：US5665747A

  公开（公告）日：1997-09-09