N-(3-Methoxybenzoyl)-2-(3-methylphenyl)ethylamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3-Methoxybenzoyl)-2-(3-methylphenyl)ethylamine
• 英文别名: 3-methoxy-N-[2-(3-methylphenyl)ethyl]benzamide
• 化学式: C₁₇H₁₉NO₂
• 分子量: 269.343
• InChiKey: WLYQSKIAKYHKTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(3-Methoxybenzoyl)-2-(3-methylphenyl)ethylamine 在 palladium on activated charcoal 、 三溴化硼 、 间氯过氧苯甲酸 、 三氯氧磷 作用下， 以 5,5-dimethyl-1,3-cyclohexadiene 、 二氯甲烷 、 氯仿 为溶剂， 反应 40.0h， 生成 1-(3-hydroxyphenyl)-8-methylisoquinoline 2-oxide
  参考文献：
  名称：

  Bifunctional Organocatalysts for the Enantioselective Synthesis of Axially Chiral Isoquinoline N-Oxides

  摘要：

  Bifunctional catalysts bearing amino and urea functional groups have been applied for a novel, highly enantioselective synthesis of axially chiral isoquinoline N-oxides, which are promising chiral ligands or organocatalysts in organic synthesis. This is the first example of highly enantioselective synthesis of axially chiral biaryls by bifunctional organocatalysts. Good-to-excellent enantioselectivities were obtained with a range of substrates.

  DOI：

  10.1021/jacs.5b04151
• 作为产物：
  描述：

  3-甲氧基苯甲酸 在 氯化亚砜 作用下， 以 乙醚 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 6.5h， 生成 N-(3-Methoxybenzoyl)-2-(3-methylphenyl)ethylamine
  参考文献：
  名称：

  Bifunctional Organocatalysts for the Enantioselective Synthesis of Axially Chiral Isoquinoline N-Oxides

  摘要：

  Bifunctional catalysts bearing amino and urea functional groups have been applied for a novel, highly enantioselective synthesis of axially chiral isoquinoline N-oxides, which are promising chiral ligands or organocatalysts in organic synthesis. This is the first example of highly enantioselective synthesis of axially chiral biaryls by bifunctional organocatalysts. Good-to-excellent enantioselectivities were obtained with a range of substrates.

  DOI：

  10.1021/jacs.5b04151

文献信息

• Substituted isoquinolines and methods of using same
  申请人：Euroceltique, S.A.

  公开号：US04956371A1

  公开（公告）日：1990-09-11

  Novel substituted isoquinoline compounds are disclosed together with novel 2-phenylethylamides useful as precursors or intermediates for the production of the isoquinolines. The substituted isoquinolines exhibit activity in antagonizing the effects of platelet activating factor (PAF).

  本专利揭示了替代异喹啉化合物，以及作为异喹啉的前体或中间体有用的新型2-苯乙基酰胺。这些替代异喹啉在拮抗血小板活化因子（PAF）的作用方面表现出活性。
• Chrysanthemum plant named ‘CIFZ0094’
  申请人：SYNGENTA CROP PROTECTION AG

  公开号：USPP034630P2

  公开（公告）日：2022-10-04

  A new garden type Chrysanthemum plant named ‘CIFZ0094’ particularly distinguished by its medium size plant with mound plant habit, medium to small sized decorative flowers with white flower color, and a natural season response early to mid-October.

  一种新的菊花园艺品种，命名为'CIFZ0094'，其特点是植株中等大小，植株形态为丘状，花朵中等到小型，花色为白色，自然生长期响应为10月初到中旬。
• Substituted isoquinolines and their use
  申请人：Euro-Celtique S.A.

  公开号：EP0422328A2

  公开（公告）日：1991-04-17

  Novel substituted isoquinoline compounds are disclosed together with novel 2-phenylethylamides useful as precursors or intermediates for the production of the isoquinolines. The substituted isoquinolines exhibit activity in antagonizing the effects of platelet activating factor (PAF).

  本研究公开了新型取代的异喹啉化合物以及可用作生产异喹啉的前体或中间体的新型 2-苯基乙酰胺。这些取代的异喹啉类化合物具有拮抗血小板活化因子（PAF）的活性。
• US4956371A
  申请人：——

  公开号：US4956371A

  公开（公告）日：1990-09-11
• USRE34630E
  申请人：——

  公开号：USRE34630E

  公开（公告）日：1994-06-07