6-(tert-butyl)cyclohex-1-en-1-yl trifluoromethanesulfonate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: 6-(tert-butyl)cyclohex-1-en-1-yl trifluoromethanesulfonate
• 英文别名: 6-tert-butyl-cyclohex-1-en-1-yl trifluoromethanesulfonate；(6-tert-butylcyclohexen-1-yl) trifluoromethanesulfonate
• 化学式: C₁₁H₁₇F₃O₃S
• 分子量: 286.315
• InChiKey: RWQYOILOZQZHEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  6-(tert-butyl)cyclohex-1-en-1-yl trifluoromethanesulfonate 在 palladium diacetate dimethyl sulfide borane 、 N,N-二异丙基乙胺 、 1,4-双(二苯基膦)丁烷 作用下， 以 甲苯 为溶剂， 反应 2.0h， 生成 (6-tert-Butyl-cyclohex-1-enyl)-diphenyl-phosphane; compound with borane
  参考文献：
  名称：

  钯催化酮类合成乙烯基膦

  摘要：

  据报道，钯催化的三氟甲基丙烯酸酯转化为乙烯基膦。该方法允许从酮合成乙烯基膦。据报道，对各种酮进行选择性烯醇化，然后随着三氟甲磺​​酸乙烯酯的捕获而捕获烯醇化物。然后通过钯催化将乙烯基三氟甲磺酸酯转化为相应的乙烯基膦。然后可以将所得的乙烯基膦还原为烷基膦。

  DOI：

  10.1016/s0040-4039(99)01819-5
• 作为产物：
  描述：

  N-苯基双(三氟甲烷磺酰)亚胺 、 2-叔-丁基环己酮 在 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以56%的产率得到6-(tert-butyl)cyclohex-1-en-1-yl trifluoromethanesulfonate
  参考文献：
  名称：

  具有手性转移的金（III）催化的乙炔胺-环戊二烯环异构化：实验和理论研究表明双Au（III）推挽辅助顺式-反式异构体的参与

  摘要：

  已通过非手性Au（III）催化从手性烯胺建立了一种合成方法，用于合成不对称环稠合的环戊二烯（Cps），该化合物在环结处具有手性碳。根据实验和理论数据，拟议的从烯胺到Cps的机理途径是通过Au（III）烯顺式-反式异构化步骤发生的。在DFT和NEVPT2水平的计算研究认为，顺式-反式异构化步骤是通过双Au（III）推挽辅助中间体进行的，其旋转势垒较低。手性传递通过具有烯丙基特征的螺旋形过渡态发生。催化的范围包括在空间上庞大的烯胺，包括萜烯天然产物。

  DOI：

  10.1021/jo501905q

文献信息

• Novel cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators
  申请人：Wyeth

  公开号：US20020198196A1

  公开（公告）日：2002-12-26

  The present invention provides novel tricyclic diazepine compounds and methods and pharmaceutical compositions utilizing them for the treating or preventing disorders including diabetes insipidus, nocturnal enuresis, nocturia, urinary incontinence, bleeding and coagulation disorders, congestive heart failure or for inducing temporary delay of urination, and in conditions with increased vascular resistance and coronary vasoconstriction; and for the treating or preventing disorders remedied or alleviated by oxytocin antagonist activity, including suppression of preterm labor, dysmenorrhea, endometritis, and for suppressing labor at term prior to caesarean delivery. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals; and treatment of disfunctions of the oxytocin system in the central nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.

  本发明提供了新颖的三环二氮杂环烷化合物，以及利用它们用于治疗或预防包括尿崩症、夜尿症、夜尿频、尿失禁、出血和凝血障碍、充血性心力衰竭或暂时延迟排尿、以及在血管阻力增加和冠状血管收缩的情况下；以及用于治疗或预防通过催产素拮抗活性得到缓解或减轻的疾病，包括抑制早产、痛经、子宫内膜炎，以及在剖宫产前抑制分娩。这些化合物还可用于提高农场动物的生育率、生存率和同步动情期；以及治疗中枢神经系统中催产素系统功能障碍，包括强迫症（OCD）和神经精神障碍。
• Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators
  申请人：Wyeth

  公开号：US07022699B2

  公开（公告）日：2006-04-04

  The present invention provides novel tricyclic diazepine compounds and methods and pharmaceutical compositions utilizing them for the treating or preventing disorders including diabetes insipidus, nocturnal enuresis, nocturia, urinary incontinence, bleeding and coagulation disorders, congestive heart failure or for inducing temporary delay of urination, and in conditions with increased vascular resistance and coronary vasoconstriction; and for the treating or preventing disorders remedied or alleviated by oxytocin antagonist activity, including suppression of preterm labor, dysmenorrhea, endometritis, and for suppressing labor at term prior to caesarean delivery. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals; and treatment of disfunctions of the oxytocin system in the central nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.

  本发明提供了新型三环二氮平化合物，以及利用它们治疗或预防疾病的方法和制药组合物，包括尿崩症、夜间遗尿、夜尿症、尿失禁、出血和凝血障碍、充血性心力衰竭或诱导暂时延迟排尿，并且在增加血管阻力和冠状动脉收缩的情况下；并用于治疗或预防通过催产素拮抗剂活性缓解的疾病，包括抑制早产、痛经、子宫内膜炎和在剖腹产前抑制足月分娩。这些化合物还可用于提高农业动物的生育率、生存率和同步发情；以及治疗中枢神经系统中催产素系统的功能障碍，包括强迫症和神经精神障碍。
• NOVEL CYCLOHEXENYL PHENYL DIAZEPINES AS VASOPRESSIN AND OXYTOCIN RECEPTOR MODULATORS
  申请人：Wyeth

  公开号：EP1377584A1

  公开（公告）日：2004-01-07
• US7022699B2
  申请人：——

  公开号：US7022699B2

  公开（公告）日：2006-04-04
• [EN] NOVEL CYCLOHEXENYL PHENYL DIAZEPINES VASOPRESSIN AND OXYTOCIN RECEPTOR MODULATORS<br/>[FR] NOUVELLES CYCLOHEXENYL-PHENYL-DIAZEPINES MODULATRICES DES RECEPTEURS DE LA VASOPRESSINE ET DE L'OCYTOCINE
  申请人：WYETH CORP

  公开号：WO2002083681A1

  公开（公告）日：2002-10-24

  The present invention provides novel tricyclic diazepine compounds and methods and pharmaceutical compositions utilizing them for the treating or preventing disorders including diabetes insipidus, nocturnal enuresis, nocturia, urinary incontinence, bleeding and coagulation disorders, congestive heart failure or for inducing temporary delay of urination, and in conditions with increased vascular resistance and coronary vasoconstriction; and for the treating or preventing disorders remedied or alleviated by oxytocin antagonist activity, including suppression of preterm labor, dysmenorrhea, endometritis, and for suppressing labor at term prior to caesarean delivery. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronising estrus in farm animals; and treatment of disfunction of the oxytocin system in the central nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.