N-(1-(benzylamino)-3-methyl-1-oxobutan-2-yl)-N-(furan-2-ylmethyl)-3-methylbut-2-enamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(1-(benzylamino)-3-methyl-1-oxobutan-2-yl)-N-(furan-2-ylmethyl)-3-methylbut-2-enamide
• 英文别名: N-benzyl-2-[furan-2-ylmethyl(3-methylbut-2-enoyl)amino]-3-methylbutanamide
• 化学式: C₂₂H₂₈N₂O₃
• 分子量: 368.476
• InChiKey: QOFMBXSTJBRJNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  62.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-呋喃甲胺 、 3,3-二甲基丙烯酸 、 苄异腈 、 异丁醛 以 水 为溶剂， 以85%的产率得到N-(1-(benzylamino)-3-methyl-1-oxobutan-2-yl)-N-(furan-2-ylmethyl)-3-methylbut-2-enamide
  参考文献：
  名称：

  Aqueous medium effects on multi-component reactions

  摘要：

  The effect of aqueous media on many organic reactions has been studied, and often those reactions exhibiting pressure acceleration are also accelerated in water. Because some specific examples of the Ugi and Passerini reactions that are inefficient under conventional conditions have been accelerated by pressure, we examined Ugi and Passerini reactions in aqueous solutions, where significant increases in efficiency were observed. These effects were correlated to the cohesive energy density of aqueous solutions. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.08.068

文献信息

• “Isocyanide-free” Ugi reactions
  作者：Laurent El Kaïm、Laurence Grimaud、Aurélie Schiltz

  DOI：10.1039/b908541f

  日期：——

  High-yielding Ugi reactions have been carried out with in situ-prepared isocyanides, derived from the reaction of bromide derivatives with silver and potassium cyanide, thus alleviating the burden of the preparation, purification and subsequent use of isocyanides in multicomponent reactions.

  利用原位制备的异氰酸酯（由溴衍生物与氰化银和氰化钾反应生成）进行了高产乌基反应，从而减轻了异氰酸酯在多组分反应中的制备、纯化和后续使用负担。
• Aqueous medium effects on multi-component reactions
  作者：Michael C. Pirrung、Koushik Das Sarma

  DOI：10.1016/j.tet.2005.08.068

  日期：2005.11

  The effect of aqueous media on many organic reactions has been studied, and often those reactions exhibiting pressure acceleration are also accelerated in water. Because some specific examples of the Ugi and Passerini reactions that are inefficient under conventional conditions have been accelerated by pressure, we examined Ugi and Passerini reactions in aqueous solutions, where significant increases in efficiency were observed. These effects were correlated to the cohesive energy density of aqueous solutions. (c) 2005 Elsevier Ltd. All rights reserved.