1-benzyl-3-methyl-2-phenyl-1H-pyrrole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1-benzyl-3-methyl-2-phenyl-1H-pyrrole
• 英文别名: 1-Benzyl-3-methyl-2-phenylpyrrole
• 化学式: C₁₈H₁₇N
• 分子量: 247.34
• InChiKey: QLKVXONXMIIYPO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  4.9
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  2-(二苄基氨基)乙醛 在 钯 氢气 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 甲醇 为溶剂， -78.0 ℃ 、101.33 kPa 条件下， 生成 1-benzyl-3-methyl-2-phenyl-1H-pyrrole
  参考文献：
  名称：

  A versatile synthesis of polysubstituted pyrroles

  摘要：

  The aldol products formed by the reaction between alpha-(N-benzyl or N-Cbz)amino aldehydes and lithium enolates of various ketones, were subjected to hydrogenolysis to give polysubstituted pyrroles in good yields (50-91%). The scope and limitations of this methodology are explored. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01203-5

文献信息

• Multicomponent reactions in PEG-400: ruthenium-catalyzed synthesis of substituted pyrroles
  作者：Srivari Chandrasekhar、Vidyavathi Patro、Lahu N. Chavan、Rambabu Chegondi、René Grée

  DOI：10.1016/j.tetlet.2014.08.105

  日期：2014.10

  An efficient and eco-friendly method for the synthesis of substituted pyrroles has been developed via ruthenium-catalyzed multicomponent reaction of ketone, amine, and ethylene glycol in PEG-400 as solvent medium without using any external ligand. The catalytic system and solvent can be recycled with the same, as well as different, ketones with minimum loss of Ru-catalyst activity.

  通过在不使用任何外部配体的情况下，通过钌催化的PEG-400中的酮，胺和乙二醇的多组分反应，开发了一种高效，环保的取代吡咯合成方法。催化体系和溶剂可以用相同或不同的酮循环使用，而Ru催化剂的活性损失最小。
• A versatile synthesis of polysubstituted pyrroles
  作者：Bharat Lagu、Meng Pan、Michael P Wachter

  DOI：10.1016/s0040-4039(01)01203-5

  日期：2001.8

  The aldol products formed by the reaction between alpha-(N-benzyl or N-Cbz)amino aldehydes and lithium enolates of various ketones, were subjected to hydrogenolysis to give polysubstituted pyrroles in good yields (50-91%). The scope and limitations of this methodology are explored. (C) 2001 Elsevier Science Ltd. All rights reserved.