十一烷酸酰肼 | 45135-30-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 十一烷酸酰肼
• 英文名称: undecanoic acid hydrazide
• 英文别名: Undecansaeure-hydrazid；Undecylsaeurehydrazid；Undecanehydrazide
• CAS: 45135-30-6
• 化学式: C₁₁H₂₄N₂O
• mdl: MFCD02127720
• 分子量: 200.324
• InChiKey: IICGGSZGDFYYBR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.909
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT

反应信息

• 作为反应物：
  描述：

  十一烷酸酰肼 在 盐酸 作用下， 以 水 为溶剂， 生成 十一烷酸
  参考文献：
  名称：

  Gusev; Radushev; Chernova, Russian Journal of General Chemistry, 1998, vol. 68, # 10, p. 1601 - 1604

  摘要：

  DOI：
• 作为产物：
  描述：

  十一酸乙酯 在 乙醇 、 一水合肼 作用下， 生成 十一烷酸酰肼
  参考文献：
  名称：

  Kyame; Fisher; Bickford, Journal of the American Oil Chemists' Society, 1947, vol. 24, p. 333

  摘要：

  DOI：

文献信息

• Synthesis, Evaluation and Molecular Docking Studies of 1,3,4-oxadiazole- 2-thiol Incorporating Fatty Acid Moiety as Antitumor and Antimicrobial Agents
  作者：Fatma Mohamed、Ahmed Hashem、Randa Swellem、Galal Nawwar

  DOI：10.2174/157018081131000072

  日期：2014.2

  A series of 1,3,4-oxadiazole-2-thiol incorporating fatty acid moieties was synthesized. The chemical structure of the synthesized compounds was established by their spectral data, elemental analysis, and their chemical behavior. Their thioglycosides derivatives and the analogous 1,2,4-triazole were also prepared. The in vitro cytotoxicty of the synthesized compounds was screened against two cell lines; breast cell line MCF-7, and liver cell line HepG2. The most potent compound is (E)-5-(heptadec-8-enyl)-1,3,4-oxadiazole-2-thiol 4f with IC50 (2.82 | µg/ml) and (3.87 µg/ml) against breast cell line MCF-7 and liver cell line HepG2 respectively. Molecular Docking study of Bcl-2 was conducted for the most potent compound, its analogues and the lowest cytotoxicty compound. The antimicrobial activity was also screened, compound (E)-5-ethyl-1,3,4-oxadiazole-2-thiol 4a showed a broad spectrum of activity. A relationship between the length of the fatty acid chain and the biological activity was noticed in the tested compounds.

  一系列含有脂肪酸基团的1,3,4-噁二唑-2-硫醇化合物被合成。通过光谱数据、元素分析和化学行为确定了合成分子的化学结构。它们的硫代糖苷衍生物及其类似的1,2,4-三唑化合物也被制备。体外细胞毒性测试对两种细胞系进行了筛选：乳腺癌细胞系MCF-7和肝癌细胞系HepG2。最具活性的化合物是(E)-5-(十七碳-8-烯基)-1,3,4-噁二唑-2-硫醇4f，其对MCF-7细胞系的IC50值为2.82 µg/ml，对HepG2细胞系的IC50值为3.87 µg/ml。对最具活性化合物、其类似物和最低细胞毒性化合物的Bcl-2分子对接研究进行了开展。抗微生物活性也被筛选，化合物(E)-5-乙基-1,3,4-噁二唑-2-硫醇4a显示出广谱活性。在测试的化合物中，注意到脂肪酸链的长度与生物活性之间存在关系。
• Organophotoreceptor with a charge transport material having two azine groups
  申请人：Jubran Nusrallah

  公开号：US20050069798A1

  公开（公告）日：2005-03-31

  Improved organophotoreceptor comprises an electrically conductive substrate and a photoconductive element on the electrically conductive substrate, the photoconductive element comprising: (a) a charge transport material having the formula where n is an integer between 2 and 6, inclusive; R 1 and R 2 are, independently, H, halogen, carboxyl, hydroxyl, thiol, cyano, nitro, aldehyde group, ketone group, an ether group, an ester group, a carbonyl group, an alkyl group, an alkaryl group, or an aryl group; X is a linking group having the formula —(CH 2 ) m —, branched or linear, where m is an integer between 0 and 20, inclusive, and one or more of the methylene groups can be optionally replaced by O, S, C═O, O═S═O, urethane, urea, an ester group, a NR 3 group, a CHR 4 group, or a CR 5 R 6 group where R 3 , R 4 , R 5 , and R 6 are, independently, H, an alkyl group, an alkaryl group, a heterocyclic group, or an aryl group; Y comprises a bond, C, N, O, S, a branched or linear —(CH 2 ) p — group where p is an integer between 0 and 10, an aromatic group, a cycloalkyl group, a heterocyclic group, or a NR 7 group where R 7 is hydrogen atom, an alkyl group, or aryl group, wherein Y has a structure selected to form n bonds with the corresponding X groups; and Z is a fluorenylidene group; and (b) a charge generating compound. Corresponding electrophotographic apparatuses and imaging methods are described.

  改进的器官光感受器包括电导基板和位于电导基板上的光电导元件，光电导元件包括：(a) 具有以下结构的电荷传输材料，其中n是2到6之间的整数，包括；R1和R2独立地为H、卤素、羧基、羟基、硫醇、氰基、硝基、醛基、酮基、醚基、酯基、羰基、烷基、烷基芳基、或芳基；X是具有以下结构的连接基团—(CH2)m—，分支或线性，其中m是0到20之间的整数，包括，其中一个或多个亚甲基基团可以选择性地被O、S、C═O、O═S═O、脲、脲、酯基、NR3基团、CHR4基团或CR5R6基团取代，其中R3、R4、R5和R6独立地为H、烷基、烷基芳基、杂环基团或芳基；Y包括键、C、N、O、S、分支或线性—(CH2)p—基团，其中p是0到10之间的整数，芳香基团、环烷基团、杂环基团或NR7基团，其中R7是氢原子、烷基或芳基，其中Y的结构被选择为与相应的X基团形成n个键；Z是芴亚甲基基团；和(b) 一个电荷生成化合物。描述了相应的静电复印设备和成像方法。
• Synthesis of acylhydrazones from lupane and 19β,28-epoxy-18α-oleanane 2,3-seco-aldehydonitriles
  作者：I. A. Tolmacheva、N. V. Galaiko、V. V. Grishko

  DOI：10.1007/s10600-010-9520-x

  日期：2010.3

  2,3-seco-Triterpene acylhydrazones, which are interesting as new biologically active compounds, were prepared by reaction of lupane and 19β,28-epoxy-18α-oleanane 2,3-seco-aldehydonitriles with acylated hydrazines.

  通过将羽扇豆和 19β,28-环氧-18α-齐墩果烷 2,3-seco-aldehydonitriles 与酰化肼反应，制备了 2,3-seco-三萜酰肼，这是一种具有生物活性的新化合物。
• Kit for Highly Sensitive Detection Assays
  申请人：Bade Steffen

  公开号：US20090104633A1

  公开（公告）日：2009-04-23

  The present invention relates to kits comprising 2,4-dichlorophenoxyacetate derivatives as well as antibodies that bind to these derivatives. Inter alia, the kits can be used to label biomolecules for analytical and diagnostic applications. Some of the compounds described here can be used to label biomolecules under physiological conditions and without having to apply in situ activation. Furthermore, the presence of spacers within the 2,4-dichlorophenoxyacetate derivatives improves their binding to antibodies.

  本发明涉及包含2,4-二氯苯氧乙酸衍生物及与其结合的抗体的试剂盒。其中，这些试剂盒可用于标记生物分子以进行分析和诊断应用。这里描述的一些化合物可在生理条件下用于标记生物分子，而无需进行原位激活。此外，2,4-二氯苯氧乙酸衍生物中存在的空间支链改善了它们与抗体的结合。
• A process for preparing graft and block copolymers
  申请人：ALLIED CORPORATION

  公开号：EP0084643A1

  公开（公告）日：1983-08-03

  A process for preparing block and/or graft copolymeric compositions by forming an intimate mixture of two or more polymers, at least one of which includes one or more amino junctions and at least one of the remaining polymers includes one or more carboxylic acid junctions and an effective amount of a phosphite compound, and thereafter heating the intimate mixture at a temperature and for a time sufficient to form the desired block and/or graft copolymers.

  一种用于制备嵌段和/或接枝共聚物组合物的工艺，其方法是将两种或两种以上的聚合物（其中至少一种聚合物包括一个或多个氨基接合点，其余至少一种聚合物包括一个或多个羧酸接合点和有效量的亚磷酸酯化合物）形成亲密混合物，然后在足以形成所需嵌段和/或接枝共聚物的温度和时间下加热亲密混合物。