acetic acid-(malonic acid monomethyl ester)-anhydride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: acetic acid-(malonic acid monomethyl ester)-anhydride
• 英文别名: Essigsaeure-(malonsaeure-monomethylester)-anhydrid；3-O-acetyl 1-O-methyl propanedioate
• 化学式: C₆H₈O₅
• 分子量: 160.127
• InChiKey: CCAMQESDFRPOKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  69.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  acetic acid-(malonic acid monomethyl ester)-anhydride 生成 溶剂黄146
  参考文献：
  名称：

  Wulfsson, Zhurnal Obshchei Khimii, 1949, vol. 19, p. 1913

  摘要：

  DOI：
• 作为产物：
  描述：

  乙酸酐 、 alkaline earth salt of/the/ methylsulfuric acid 在 硫酸 作用下， 生成 acetic acid-(malonic acid monomethyl ester)-anhydride
  参考文献：
  名称：

  Wulfsson, Zhurnal Obshchei Khimii, 1949, vol. 19, p. 1913

  摘要：

  DOI：

文献信息

• PROCESS FOR PRODUCING PURIFIED PROSTAGLANDIN DERIVATIVE
  申请人：Asahi Glass Co., Ltd.

  公开号：EP1085012A1

  公开（公告）日：2001-03-21

  A process for producing a purified prostaglandin derivative having a high purity which comprises adding an alkene (1) to cyclopentenone (2) under the action of an alkyl lithium and an organic copper reactant to give an adduct; reacting the adduct with a carboxylic anhydride (4), etc. to give a prostaglandin derivative (6); and then treating the derivative (6) with a nitrogen-containing compound such as 2,2'-bipyridyl to thereby efficiently remove the organic copper reactant employed in the synthesis and by-products derived therefrom.

  一种生产高纯度纯化前列腺素衍生物的工艺，包括在烷基锂和有机铜反应物的作用下将烯烃（1）加到环戊烯酮（2）中，得到加合物；将加合物与羧酸酐（4）等反应，得到前列腺素衍生物（6）；然后用含氮化合物如2,2'-联吡啶处理衍生物（6），从而有效地除去有机铜反应物。然后用含氮化合物（如 2,2'-联吡啶）处理衍生物 (6)，从而有效地除去合成过程中使用的有机铜反应物以及由此产生的副产品。
• SZILACYI, G.;KASZIREINER, E.;MATYUS, P.;KOSARY, J.;CZAKO, K.;CSEH, G.;HUS+, EUR. J. MED. CHEM., 1984, 19, N 2, 111-117
  作者：SZILACYI, G.、KASZIREINER, E.、MATYUS, P.、KOSARY, J.、CZAKO, K.、CSEH, G.、HUS+

  DOI：——

  日期：——
• METHANOL PLANT RETROFIT FOR MANUFACTURE OF ACETIC ACID
  申请人：Acetex (Cyprus) Limited

  公开号：EP1226103A1

  公开（公告）日：2002-07-31
• US6632958B1
  申请人：——

  公开号：US6632958B1

  公开（公告）日：2003-10-14
• [EN] METHANOL PLANT RETROFIT FOR MANUFACTURE OF ACETIC ACID<br/>[FR] RATTRAPAGE D'INSTALLATION DE PRODUCTION DE METHANOL, POUR LA FABRICATION D'ACIDE ACETIQUE
  申请人：ACETEX CYPRUS LTD

  公开号：WO2001032594A1

  公开（公告）日：2001-05-10

  The retrofitting of an existing methanol or methanol/ammonia plant to make acetic acid is disclosed. The existing plant has a reformer (10) to which natural gas or another hydrocarbon and steam (water) are fed. Syngas is formed in the reformer (10). All or part of the syngas is processed to separate out carbon dioxide (24), carbon monoxide (30) and hydrogen (32), and the separated carbon dioxide (24) is fed either to the existing methanol synthesis loop (12) for methanol synthesis, or back into the feed to the reformer (10) to enhance carbon monoxide formation in the syngas (18). Any remaining syngas (38) not fed to the carbon dioxide separator (22) can be converted to methanol in the existing methanol synthesis loop (12) along with carbon dioxide (24) from the separator (22) and/or imported carbon dioxide (25), and hydrogen (35) from the separator (28). The separated carbon monoxide (30) is then reacted with the methanol (36) to produce acetic acid (40) or an acetic acid precursor by a conventional process. Also disclosed is the reaction of separated hydrogen (32) with nitrogen (52), in a conventional manner, to produce ammonia. Also disclosed is the reaction of a portion of the acetic acid (40) in a conventional manner with oxygen (46) and ethylene (44) to form vinyl acetate monomer (48). The nitrogen for the added ammonia capacity in a retrofit of an original methanol plant comprising an ammonia synthesis loop (33), and the oxygen (46) for the vinyl acetate monomer process (42), are obtained from a new air separation unit (50).