pyridine-2,6-diylbis(bis(4-(trifluoromethyl)phenyl)phosphine oxide)

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: pyridine-2,6-diylbis(bis(4-(trifluoromethyl)phenyl)phosphine oxide)
• 英文别名: 2,6-Bis[bis[4-(trifluoromethyl)phenyl]phosphoryl]pyridine
• 化学式: C₃₃H₁₉F₁₂NO₂P₂
• 分子量: 751.448
• InChiKey: UGWKQYOFISOZGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.3
• 重原子数：
  50
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  47
• 氢给体数：
  0
• 氢受体数：
  15

反应信息

• 作为产物：
  描述：

  2,6-二氯吡啶 、 bis(4-(trifluoromethyl)phenyl)phosphine oxide 在 palladium diacetate 、 caesium carbonate 、 双(2-二苯基磷苯基)醚 作用下， 以 甲苯 为溶剂， 反应 20.0h， 以82%的产率得到pyridine-2,6-diylbis(bis(4-(trifluoromethyl)phenyl)phosphine oxide)
  参考文献：
  名称：

  一种通过 Pd 催化磷酸化制备包含杂环片段的非对称双（叔氧化膦）的方法

  摘要：

  通过连续引入氧化膦基团，以良好的收率合成了具有不同五元和六元杂环片段的非对称叔氧化膦，例如吡啶、2,2'-联吡啶、1,10-菲咯啉、喹啉、咪唑和噻唑通过 Pd 催化的磷酸化反应进入初始的二卤化杂环。吡啶类化合物的合成受到竞争性双偶联的阻碍，而对于五元杂环，主要困难是脱卤。通过使用过量的二卤化物（在产品纯化步骤中可以很容易地回收）、钯的合适膦配体和非极性溶剂（如甲苯）成功地抑制了这两个副过程。

  DOI：

  10.1055/s-0040-1706419

文献信息

• ORGANIC ELECTROLUMINESCENCE ELEMENT
  申请人：Satou Tasuku

  公开号：US20080241518A1

  公开（公告）日：2008-10-02

  An organic electroluminescence element having at least one organic layer including a light-emitting layer between a pair of electrodes, wherein the organic electroluminescence element has an electron transport layer containing a phosphine oxide compound and an electron transport layer that does not substantially contain the phosphine oxide compound between the light-emitting layer and a cathode, the electron transport layer containing the phosphine oxide compound is nearer to the cathode, and the electron transport layer that does not substantially contain the phosphine oxide compound is nearer to the light-emitting layer. An organic EL element that exhibits high light-emission efficiency and is excellent in drive durability is provided.
• ORGANIC ELECTROLUMINESCENT DEVICE
  申请人：FUKUNAGA Hirofumi

  公开号：US20080241589A1

  公开（公告）日：2008-10-02

  An organic electroluminescent device is provided and includes: a pair of electrodes; and an organic compound layer between the pair of electrodes, the organic compound layer including a light-emitting layer. The at least one organic compound layer contains at least one of a compound represent by formula (I) and a compound represented by formula (II).
• An Approach to Nonsymmetric Bis(tertiary phosphine oxides) Comprising Heterocyclic Fragments via the Pd-Catalyzed Phosphorylation
  作者：Gladis G. Zakirova、Dmitrii Yu. Mladentsev、Nataliya N. Borisova

  DOI：10.1055/s-0040-1706419

  日期：2020.11

  imidazole, and thiazole were synthesized in good yields via the successive introduction of phosphine oxide groups into the initial dihalogenated heterocycles by means of Pd-catalyzed phosphorylation reaction. The synthesis of pyridine-type compounds is hindered by competing double coupling, while for five-membered heterocycles the principal difficulty is the dehalogenation. Both side processes were successfully

  通过连续引入氧化膦基团，以良好的收率合成了具有不同五元和六元杂环片段的非对称叔氧化膦，例如吡啶、2,2'-联吡啶、1,10-菲咯啉、喹啉、咪唑和噻唑通过 Pd 催化的磷酸化反应进入初始的二卤化杂环。吡啶类化合物的合成受到竞争性双偶联的阻碍，而对于五元杂环，主要困难是脱卤。通过使用过量的二卤化物（在产品纯化步骤中可以很容易地回收）、钯的合适膦配体和非极性溶剂（如甲苯）成功地抑制了这两个副过程。