Chemoselectivity in the ruthenium-catalyzed redox isomerization of allyl alcohols
作者:Barry M. Trost、Robert J. Kulawiec
DOI:10.1021/ja00058a059
日期:1993.3
Adjustment of oxidation level by internalhydrogen reorganization represents a highly efficient synthetic protocol. Cyclopentadienylbis(triphenylphosphine)ruthenium chloride in the presence of triethylammonium hexafluorophosphate catalyzes the redox isomerization of allyl alcohols to their saturated aldehydes or ketones. High chemoselectivity is observed since simple primary and secondary alcohols
Stereoselective Dehydroxyboration of Allylic Alcohols to Access (<i>E</i>)-Allylboronates by a Combination of C–OH Cleavage and Boron Transfer under Iron Catalysis
Iron-catalyzed direct SN2′ dehydroxyboration of allylic alcohols has been developed to access (E)-stereoselective allylboronates. Allylic alcohols with diverse structures and functional groups, especially derived from natural products, underwent smooth transformation. The six-membered ring transition state formed by allylic alcohols and iron–boron intermediate was indicated to be the key component
铁催化的烯丙醇直接 S N 2' 脱羟基硼酸已被开发用于获得 ( E )-立体选择性烯丙基硼酸酯。具有多种结构和官能团的烯丙醇,特别是来自天然产物的烯丙醇,经历了平稳的转变。由烯丙醇和铁-硼中间体形成的六元环过渡态被证明是参与硼基团转移、C-OH键活化和立体选择性控制的关键成分。
A relay ring-opening/double ring-closing metathesis strategy for the bicyclic macrolide-butenolide core structures
作者:Mahesh B. Halle、Rodney A. Fernandes
DOI:10.1039/c4ra10937f
日期:——
been developed for the synthesis of the bicyclic macrolide-butenolide core structures of various natural products with the macrolide ring size ranging from 12- to 16-membered. The bicyclic structure was easily assembled using the relay ring-opening/double ring-closingmetathesis strategy. An efficient synthesis of (±)-desmethyl manshurolide has been achieved as an application of this strategy.
Total Synthesis of 34-Hydroxyasimicin and Its Photoactive Derivative for Affinity Labeling of the Mitochondrial Complex I
作者:Hongna Han、Mantosh K. Sinha、Lawrence J. D'Souza、Ehud Keinan、Subhash C. Sinha
DOI:10.1002/chem.200305557
日期:2004.5.3
total synthesis of the 34-hydroxyasimicin and its 3-(4-benzoylphenyl)propionate ester was achieved by means of a convergent synthetic strategy. This ester, which contains eight asymmetric centers, represents the first photoaffinity-labeling agent that is derived from an Annonaceous acetogenin. The key transformations in the synthesis include the Sharpless asymmetric dihydroxylation reaction, the Wittig
Aliphatic polyketones via cross-metathesis polymerization: Synthesis and post-polymerization modification
作者:Fu-Rong Zeng、Jing Xu、Qi Xiong、Kai-Xuan Qin、Wei-Jun Xu、Yue-Xin Wang、Zan-Jiao Liu、Zi-Long Li、Zi-Chen Li
DOI:10.1016/j.polymer.2019.121936
日期:2019.12
α-olefin and vinylketone units of monomer 2. Optimization of polymerization condition was conducted to generate unsaturated polyketone P0 (Mn,GPC = 14 kDa), and the results of kinetic study verified high efficiency and structural integrity of this system. Furthermore, post-polymerization modification of P0 by using thiol-Michael chemistry furnished functional polyketones P1–P6, and full conversion of the