4,5-dibromo-1-methyl-2-(3-pyridyl)imidazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4,5-dibromo-1-methyl-2-(3-pyridyl)imidazole
• 英文别名: 3-(4,5-Dibromo-1-methylimidazol-2-yl)pyridine；3-(4,5-dibromo-1-methylimidazol-2-yl)pyridine
• 化学式: C₉H₇Br₂N₃
• 分子量: 316.983
• InChiKey: BVDHQPFYLQXROD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-碘吡啶 、 4,5-二溴-1-甲基-1H-咪唑 在 [Pd(1,10-phenanthroline)₂](PF₆)₂ 、 potassium carbonate 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 反应 20.0h， 以74%的产率得到4,5-dibromo-1-methyl-2-(3-pyridyl)imidazole
  参考文献：
  名称：

  Facile Synthetic Method for Diverse Polyfunctionalized Imidazoles by Means of Pd-Catalyzed C–H Bond Arylation of N-Methyl-4,5-dibromoimidazole

  摘要：

  C-H bond-selective arylation reaction of 4,5-dibromoimidazole with aryl iodides, catalyzed by the palladium-1,10-phenanthroline complex [Pd(phen)(2)](PF6)(2), has been developed. The process tolerates the presence of a variety of functional groups on the aryl halide substrates. The products formed in these reactions were transformed to a variety of polyfunctionalized imidazoles by taking advantage of selective reactions of remaining C-Br bonds.

  DOI：

  10.1021/jo5013493

文献信息

• Facile Synthetic Method for Diverse Polyfunctionalized Imidazoles by Means of Pd-Catalyzed C–H Bond Arylation of <i>N</i>-Methyl-4,5-dibromoimidazole
  作者：Takayuki Yamauchi、Fumitoshi Shibahara、Toshiaki Murai

  DOI：10.1021/jo5013493

  日期：2014.8.1

  C-H bond-selective arylation reaction of 4,5-dibromoimidazole with aryl iodides, catalyzed by the palladium-1,10-phenanthroline complex [Pd(phen)(2)](PF6)(2), has been developed. The process tolerates the presence of a variety of functional groups on the aryl halide substrates. The products formed in these reactions were transformed to a variety of polyfunctionalized imidazoles by taking advantage of selective reactions of remaining C-Br bonds.