methyl 1-[N-(3-methylbutyl)-carbamoyl]-cyclopentanecarboxylate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 1-[N-(3-methylbutyl)-carbamoyl]-cyclopentanecarboxylate
• 英文别名: methyl 1-[N-(3-methylbutyl)carbamoyl]cyclopentanecarboxylate；methyl 1-(3-methylbutylcarbamoyl)cyclopentane-1-carboxylate
• 化学式: C₁₃H₂₃NO₃
• 分子量: 241.331
• InChiKey: QZAKIRBSJGQZFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl 1-[N-(3-methylbutyl)-carbamoyl]-cyclopentanecarboxylate 在 盐酸 、 sodium hydroxide 作用下， 以 四氢呋喃 为溶剂， 生成 ({[(3-methylbutyl)amino]methyl}cyclopentyl)methan-1-ol
  参考文献：
  名称：

  Substituted cycloalkyls as inhibitors of a beta protein production

  摘要：

  这项发明涉及具有化学式(I)的新型内酰胺，以及它们的药物组合物和使用方法。这些新型化合物抑制淀粉样前体蛋白的加工，更具体地说，抑制Aβ-肽的产生，从而防止淀粉样蛋白在神经系统中沉积的形成。更具体地，本发明涉及与β-淀粉样蛋白产生相关的神经系统疾病的治疗，如阿尔茨海默病和唐氏综合征。

  公开号：

  US20020061874A1
• 作为产物：
  描述：

  cyclopentane-1,1-dicarboxylic acid monomethyl ester 、 异戊胺 在 1-羟基苯并三唑 、 1,2-二氯乙烷 作用下， 生成 methyl 1-[N-(3-methylbutyl)-carbamoyl]-cyclopentanecarboxylate
  参考文献：
  名称：

  Cyclic malonamides as inhibitors of a beta protein production

  摘要：

  这项发明涉及具有式(I)的新型环状马隆酰胺，以及它们的药物组合物和使用方法。这些新型化合物抑制淀粉样前体蛋白的加工，更具体地抑制Aβ-肽的产生，从而预防淀粉样蛋白的神经沉积形成。更具体地说，本发明涉及与β-淀粉样蛋白产生相关的神经系统疾病的治疗，如阿尔茨海默病和唐氏综合征。

  公开号：

  US20020103184A1

文献信息

• Cyclic malonamides as inhibitors of Abeta protein protection
  申请人：Olson E. Richard

  公开号：US20060135762A1

  公开（公告）日：2006-06-22

  This invention relates to novel cyclic malonamides having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.

  本发明涉及一种新型环状马隆酰胺，其化学式为（I）：以及其药物组合物和使用方法。这些新化合物抑制淀粉样前体蛋白的加工，更具体地抑制Aβ肽的产生，从而防止神经元内淀粉样蛋白的沉积。更具体地，本发明涉及与β-淀粉样蛋白产生相关的神经系统疾病的治疗，例如阿尔茨海默病和唐氏综合症。
• Cyclic malonamides as inhibitors of A-Beta protein production
  申请人：Olson E. Richard

  公开号：US20050009807A1

  公开（公告）日：2005-01-13

  This invention relates to novel cyclic malonamides having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.

  本发明涉及具有公式（I）的新型环状马隆酰胺、其药物组合物以及使用方法。这些新型化合物抑制淀粉样前体蛋白的加工，更具体地抑制Aβ-肽的产生，从而防止神经沉积物的淀粉样蛋白形成。更具体地，本发明涉及与β-淀粉样蛋白产生相关的神经系统疾病的治疗，例如阿尔茨海默病和唐氏综合症。
• Cyclic malonamides as inhibitors of a&bgr; protein production
  申请人：——

  公开号：US06759404B2

  公开（公告）日：2004-07-06

  Novel cyclic malonamides having the formula (I): and their pharmaceutical compositions. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A&bgr;-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein.

  具有以下式子（I）的新型环状马龙酰胺及其制药组合物。这些新型化合物抑制淀粉样前体蛋白的加工，更具体地抑制Aβ肽的产生，从而防止淀粉样蛋白的神经沉积形成。
• CYCLIC MALONAMIDES AS INHIBITORS OF ABETA PROTEIN PRODUCTION
  申请人：Olson Richard E.

  公开号：US20100009965A1

  公开（公告）日：2010-01-14

  This invention relates to novel cyclic malonamides having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.

  本发明涉及具有公式（I）的新型环状马隆酰胺，其药物组成物和使用方法。这些新化合物抑制淀粉样前体蛋白的加工，更具体地抑制Aβ-肽的产生，从而防止神经沉积物的淀粉样蛋白形成。更具体地，本发明涉及治疗与β-淀粉样蛋白产生相关的神经疾病，如阿尔茨海默病和唐氏综合症。
• CYCLIC MALONAMIDES AS INHIBITORS OF Abeta PROTEIN PRODUCTION
  申请人：Olson Richard E.

  公开号：US20090264419A1

  公开（公告）日：2009-10-22

  This invention relates to novel cyclic malonamides having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.

  本发明涉及具有以下公式（I）的新型环状马隆酰胺、其制药组合物以及使用方法。这些新化合物抑制淀粉样前体蛋白的加工，更具体地抑制Aβ-肽的产生，从而防止神经沉积物的淀粉样蛋白形成。更具体地，本发明涉及与β-淀粉样蛋白产生有关的神经系统疾病的治疗，例如阿尔茨海默病和唐氏综合症。