cis-2,3,3a,8a-tetrahydrocyclopenta[a]inden-8(1H)-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: cis-2,3,3a,8a-tetrahydrocyclopenta[a]inden-8(1H)-one
• 英文别名: cis-1.2.3.3a.8.8a-Hexahydro-cyclopentinden-8-on；1,2,3,3a,8,8a-Hexahydrocyclopentinden-8-on；(3aS,8bR)-2,3,3a,8b-tetrahydro-1H-cyclopenta[a]inden-4-one
• 化学式: C₁₂H₁₂O
• 分子量: 172.227
• InChiKey: FXTMTYSWYBRYPJ-ONGXEEELSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  cis-2,3,3a,8a-tetrahydrocyclopenta[a]inden-8(1H)-one 在 硫酸羟胺 作用下， 以 四氢呋喃 、 乙醇 、 水 为溶剂， 生成
  参考文献：
  名称：

  Dihydroquinolines as Novel n-NOS Inhibitors

  摘要：

  Dihydroquinolines have been synthesized and have been shown to be potent n-NOS inhibitors. Selectivity versus e-NOS was increased to approximately 100-fold through appropriate substitution at the benzene ring. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00481-x
• 作为产物：
  描述：

  1-环戊烯羧酸 在 三氯化铝 、 氯化亚砜 作用下， 生成 cis-2,3,3a,8a-tetrahydrocyclopenta[a]inden-8(1H)-one
  参考文献：
  名称：

  Dihydroquinolines as Novel n-NOS Inhibitors

  摘要：

  Dihydroquinolines have been synthesized and have been shown to be potent n-NOS inhibitors. Selectivity versus e-NOS was increased to approximately 100-fold through appropriate substitution at the benzene ring. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00481-x

文献信息

• Cyclization of (2-Alkenylphenyl)carbonyl Compounds to Polycyclic Arenes Catalyzed by Copper(II) Trifluoromethanesulfonate or Trifluoromethanesulfuric Acid
  作者：Wei-Min Liu、Ya Lin Tnay、Kian Ping Gan、Zhen-Hong Liu、Wan Huei Tyan、Koichi Narasaka

  DOI：10.1002/hlca.201200396

  日期：2012.10

  Various polycyclic arenes, such as naphthalenes, tetrahydroantharacenes, tetrahydrotetracenes, dihydropentacenes, and dihydropentaphenes are prepared from 2‐alkenylphenyl ketones and aldehydes by the catalytic use of copper(II) trifluoromethanesulfonate (Cu(OTf)2) or trifluoromethanesulfuric acid (TfOH).

  通过催化使用三氟甲磺酸铜（II）（Cu（OTf）2）或三氟甲磺酸（TfOH）的催化作用，由2-烯基苯基酮和醛制备各种多环芳烃，例如萘，四氢蒽烷，四氢四氢萘，二氢戊四烯和二氢戊苯。
• Synthesis of compounds with potential psychotomimetic activity. IV
  作者：Edward R. Freiter、Joseph G. Cannon、Larry D. Milne、Leo G. Abood

  DOI：10.1021/jm00311a029

  日期：1968.9
• McIntyre,D. et al., Journal of the Chemical Society C: Organic, 1966, p. 985 - 989
  作者：McIntyre,D. et al.

  DOI：——

  日期：——
• Foehlisch,B.; Schwaiger,G., Justus Liebigs Annalen der Chemie, 1975, p. 1 - 18
  作者：Foehlisch,B.、Schwaiger,G.

  DOI：——

  日期：——
• Dihydroquinolines as Novel n-NOS Inhibitors
  作者：Stefan Jaroch、Peter Hölscher、Hartmut Rehwinkel、Detlev Sülzle、Gerardine Burton、Margrit Hillmann、Fiona M. McDonald

  DOI：10.1016/s0960-894x(02)00481-x

  日期：2002.9

  Dihydroquinolines have been synthesized and have been shown to be potent n-NOS inhibitors. Selectivity versus e-NOS was increased to approximately 100-fold through appropriate substitution at the benzene ring. (C) 2002 Elsevier Science Ltd. All rights reserved.