(E)-2,3-dimethoxy-3',4'-dimethoxychalcone

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (E)-2,3-dimethoxy-3',4'-dimethoxychalcone
• 英文别名: 2.3.3'.4'-tetramethoxy-trans-chalcone；2.3.3'.4'-Tetramethoxy-trans-chalkon；(2E)-3-(2,3-Dimethoxyphenyl)-1-(3,4-dimethoxyphenyl)prop-2-en-1-one；(E)-3-(2,3-dimethoxyphenyl)-1-(3,4-dimethoxyphenyl)prop-2-en-1-one
• 化学式: C₁₉H₂₀O₅
• 分子量: 328.365
• InChiKey: KHZBNBAMBIGBMC-CSKARUKUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3,4-二甲氧基苯乙酮 、 2,3-二甲氧基苯甲醛 在 氢氧化钾 、 乙醇 作用下， 生成 (E)-2,3-dimethoxy-3',4'-dimethoxychalcone
  参考文献：
  名称：

  v.Hornstein, 1923, vol. 3, p. 75,79

  摘要：

  DOI：

文献信息

• v.Hornstein, 1923, vol. 3, p. 75,79
  作者：v.Hornstein

  DOI：——

  日期：——
• Synthesis and crystal structure of chalcones as well as on cytotoxicity and antibacterial properties
  作者：Jianzhang Wu、Cong Wang、Yuepiao Cai、Jing Peng、Donglou Liang、Yunjie Zhao、Shulin Yang、Xiaokun Li、Xiaoping Wu、Guang Liang

  DOI：10.1007/s00044-011-9549-9

  日期：2012.4

  A series of chalcones derivatives were synthesized and evaluated for cytotoxic and antibacterial activities in vitro. These modifications changed their bioactivity profile and indicated a combination of SAR analysis toward the substituents in rings A and B of chalcones. Compounds 2, 6-8, 14-17, and 32 exhibited good cytotoxic properties against two human cancer cell lines HT29 and SGC7901. Compounds 16 and 17 showed high antibacterial activity toward 14 clinically isolated multidrug-resistant strains. Subsequently, the structure of bi-bioactive compound 16 was determined using single-crystal X-ray diffraction. This study presents a few novel leading compounds for the development of potential antitumor and antibacterial agents.