tris-(3-pyridyl)phosphite

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: tris-(3-pyridyl)phosphite
• 英文别名: tri(3-pyridyl) phosphite；Tripyridin-3-yl phosphite
• 化学式: C₁₅H₁₂N₃O₃P
• 分子量: 313.252
• InChiKey: RPTJJQDTMCDDNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-羟基吡啶 在 三乙胺 、 三氯化磷 作用下， 以 四氢呋喃 为溶剂， 以53%的产率得到tris-(3-pyridyl)phosphite
  参考文献：
  名称：

  Encapsulation of Transition Metal Catalysts by Ligand-Template Directed Assembly

  摘要：

  Encapsulated transition metal catalysts are presented that are formed by templated self-assembly processes of simple building blocks such as porphyrins and pyridylphosphine and phosphite ligands, using selective metal-ligand interactions. These ligand assemblies coordinate to transition metals, leading to a new class of transition metal catalysts. The assembled catalyst systems were characterized using NMR and UV-vis spectroscopy and were identified under catalytic conditions using high-pressure infrared spectroscopy. Tris-3-pyridylphosphine binds three mesophenyl zinc(II) porphyrin units and consequently forms an assembly with the phosphorus donor atom completely encapsulated. The encapsulated phosphines lead exclusively to monoligated transition metal complexes, and in the rhodium-catalyzed hydroformylation of 1-octene the encapsulation of the catalysts resulted in a 10-fold increase in activity. In addition, the branched aldehyde was formed preferentially (l/b = 0.6), a selectivity that is highly unusual for this substrate, which is attributed to the encapsulation of the transition metal catalysts. An encapsulated rhodium catalyst based on ruthenium(II) porphyrins and tris-meta-pyridyl phosphine resulted in an even larger selectivity for the branched product (l/b = 0.4). These encapsulated catalysts can be prepared easily, and various template ligands and porphyrins, such as tris-3-pyridyl phosphite and ruthenium(l I) porphyrins, have been explored, leading to catalysts with different properties.

  DOI：

  10.1021/ja0386795

文献信息

• Processes for the preparation of 0-(2-aminobenzo[d]oxazol-5-yl)methyl hydroxylamine for the synthesis of 6,11-bicyclic erythromycin derivative EDP-182
  申请人：Xu Guoyou

  公开号：US20070207972A1

  公开（公告）日：2007-09-06

  The present invention relates to processes and intermediates for the preparation of 6-11 bicyclic erythromycin derivative known as EDP-182 (IX-a). In particular, the present invention relates to processes and intermediates for the preparation of O-(2-aminobenzo[d]oxazol-5-yl)methyl hydroxylamine:

  本发明涉及用于制备被称为EDP-182（IX-a）的6-11环式红霉素衍生物的过程和中间体。具体而言，本发明涉及用于制备O-(2-氨基苯并[d]噁唑-5-基)甲基羟胺的过程和中间体。
• 6-O-substituted erythromycin derivatives having improved gastrointestinal tolerance
  申请人：Ma Zhenkun

  公开号：US20060166906A1

  公开（公告）日：2006-07-27

  Compounds having formula (I) are useful for treating bacterial infections while avoiding the concomitant liability of gastrointestinal intolerance. Compositions containing the compounds and methods of treatment using the compounds are also disclosed.

  具有化学式（I）的化合物可用于治疗细菌感染，同时避免胃肠不耐受的风险。含有这些化合物的组合物以及使用这些化合物进行治疗的方法也被揭示。
• [EN] BRIDGED MACROCYCLIC COMPOUNDS AND PROCESSES FOR THE PREPARATION THEREOF<br/>[FR] COMPOSES MACROCYCLIQUES PONTES ET PROCEDES DE PREPARATION DESDITS COMPOSES
  申请人：ENANTA PHARM INC

  公开号：WO2005080408A1

  公开（公告）日：2005-09-01

  The present invention provides a method for preparing bridged macrocyclic compounds comprising the step of reacting a macrocyclic compound characterized by having at least two nucleophilic moieties with a bifunctional bridging reagent optionally in the presence of a catalyst, thereby producing a bridged macrocyclic product.

  本发明提供了一种制备桥联大环化合物的方法，包括以下步骤：将至少具有两个亲核基团的大环化合物与双功能桥接试剂反应，可选地在催化剂的存在下进行，从而产生桥联大环产物。
• [EN] PROCESS FOR THE PREPARATION OF T-11 BICYCLIC ERYTHROMYCIN DERIVATIVES<br/>[FR] PROCEDE DE PREPARATION DE DERIVES BICYCLIQUES 6-11 D'ERYTHROMYCINE
  申请人：ENANTA PHARM INC

  公开号：WO2005070918A1

  公开（公告）日：2005-08-04

  The present invention relates to processes and intermediates for the preparation of 6-11 bicyclic erythromycin derivatives. In particular, the presen tinvention relates to processes and intermediates for the preparation of a compound of formula (IX-c).

  本发明涉及用于制备6-11双环红霉素衍生物的过程和中间体。具体而言，本发明涉及用于制备化合物（IX-c）的过程和中间体。
• A Versatile Protocol for the Synthesis of Pyrazolyl-Substituted Pyridinium and Guanidinium Salts from Pyridone and Urea Derivatives
  作者：Antje K. C. Echterhoff、Sivathmeehan Yogendra、Jutta Kösters、Roland Fischer、Jan J. Weigand

  DOI：10.1002/ejoc.201403057

  日期：2014.12

  The trication (pyr3P2)3+ (1+, pyr = 3,5-dimethylpyrazolyl) is used as a convenient pyrazolyl-transfer reagent to convert 2-pyridones, 4-pyridones, and urea derivatives to pyrazolyl-substituted pyridinium or guanidinium triflate salts. This conversion represents a new, efficient, and highly functional-group-compatible approach that yields the desired products conveniently and in high yields. Typically

  三阳离子 (pyr3P2)3+ (1+, pyr = 3,5-二甲基吡唑基) 用作方便的吡唑基转移试剂，可将 2-吡啶酮、4-吡啶酮和尿素衍生物转化为吡唑基取代的吡啶鎓或胍鎓三氟甲磺酸盐. 这种转化代表了一种新的、高效的、与官能团高度兼容的方法，可以方便地以高产率生产所需的产品。通常，该反应通过将底物的羰基氧原子交换为吡唑基部分而进行。然而，对于结构相关的 3-羟基吡啶，会发生不同的反应途径以产生亚磷酸三吡啶酯。反应的结果可以通过底物的内酰胺-内酰胺互变异构现象来解释，并进行了详细讨论。所有反应产物均通过元素分析和多核 NMR、IR、