半乳糖醛酸 | 489-91-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 半乳糖醛酸
• 英文名称: D-taluronic acid
• 英文别名: β-D-talopyranuronic acid；D-Taluronsaeure；Beta-D-Talopyranuronic Acid；(2S,3R,4S,5S,6R)-3,4,5,6-tetrahydroxyoxane-2-carboxylic acid
• CAS: 489-91-8；528-16-5；552-12-5；577-46-8；643-33-4；2240-07-5；6294-16-2；10133-02-5；18402-78-3；18968-14-4；21179-08-8；23018-83-9；33599-45-0；33599-46-1；46171-67-9；46171-69-1；46172-26-3；70021-34-0；71031-08-8；104195-06-4；106499-29-0；124817-72-7
• 化学式: C₆H₁₀O₇
• 分子量: 194.141
• InChiKey: AEMOLEFTQBMNLQ-BYVYFCENSA-N

物化性质

• 熔点：
  142-144 °C
• 沸点：
  495.2±45.0 °C(Predicted)
• 密度：
  1.987±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  127
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• CARBOHYDRATE-GLYCOLIPID CONJUGATE VACCINES
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：US20150238597A1

  公开（公告）日：2015-08-27

  The present invention relates to the field of synthesizing and biologically evaluating of a novel class of carbohydrate-based vaccines. The new vaccines consist of a multi-modular structure which allows applying the vaccine to a whole variety of pathogenes. This method allows preparing vaccines against all pathogens expressing immunogenic carbohydrate antigens. As conjugation of antigenic carbohydrates to proteins is not required the conjugate vaccine is particularly heat stable. No refrigeration is required, a major drawback of protein-based vaccines.

  本发明涉及合成和生物评价一种新型基于碳水化合物的疫苗的领域。这种新疫苗由多模块结构组成，可以将疫苗应用于各种病原体。该方法允许制备针对所有表达免疫原碳水化合物抗原的病原体的疫苗。由于不需要将抗原碳水化合物与蛋白质结合，所以结合疫苗尤其耐热稳定。无需冷藏，这是基于蛋白质的疫苗的一个主要缺点。
• Carbohydrate-glycolipid conjugate vaccines
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：US10588962B2

  公开（公告）日：2020-03-17

  The present invention relates to the field of synthesizing and biologically evaluating of a novel class of carbohydrate-based vaccines. The new vaccines consist of a multi-modular structure which allows applying the vaccine to a whole variety of pathogenes. This method allows preparing vaccines against all pathogens expressing immunogenic carbohydrate antigens. As conjugation of antigenic carbohydrates to proteins is not required the conjugate vaccine is particularly heat stable. No refrigeration is required, a major drawback of protein-based vaccines.

  本发明涉及一类基于碳水化合物的新型疫苗的合成和生物评估领域。这种新型疫苗由多模块结构组成，可将疫苗应用于各种病原体。这种方法可以制备出针对所有表达免疫原性碳水化合物抗原的病原体的疫苗。由于不需要将抗原碳水化合物与蛋白质共轭，共轭疫苗的热稳定性特别好。无需冷藏，这是基于蛋白质的疫苗的一个主要缺点。
• [EN] CARBOHYDRATE-GLYCOLIPID CONJUGATE VACCINES<br/>[FR] VACCINS CONJUGUANT UN HYDRATE DE CARBONE ET UN GLYCOLIPIDE
  申请人：MAX PLANCK GESELLSCHAFT

  公开号：WO2013178236A1

  公开（公告）日：2013-12-05

  The present invention relates to the field of synthesizing and biologically evaluating of a novel class of carbohydrate-based vaccines. The new vaccines consist of a multi-modular structure wherein a carbohydrate antigen is covalently bound to a glycolipid adjuvant. This method allows preparing vaccines against all pathogens expressing immunogenic carbohydrate antigens. As conjugation of antigenic carbohydrates to proteins is not required the conjugate vaccine is particularly heat stable. No refrigeration is required, a major drawback of protein-based vaccines.