2,4,6-triphenyl-2H-chromen-2-ol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2,4,6-triphenyl-2H-chromen-2-ol
• 英文别名: 2,4,6-Triphenylchromen-2-ol
• 化学式: C₂₇H₂₀O₂
• 分子量: 376.455
• InChiKey: VVJVAZSQJFIVPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  对羟基联苯 、 反式-查耳酮 在 三氟乙酸 作用下， 反应 72.0h， 以66%的产率得到2,4,6-triphenyl-2H-chromen-2-ol
  参考文献：
  名称：

  TFA-Mediated Tandem Friedel−Crafts Alkylation/Cyclization/Hydrogen Transfer Process for the Synthesis of Flavylium Compounds

  摘要：

  [Graphics]The tandem reaction of phenols and chalcones in refluxing TFA gave the flavylium species of 2-hydroxy-2-phenyl-2H-chromenes in moderate to good isolated yields. The reaction was proposed to involve a tandem transformation of Friedel-Crafts alkylation, dehydrative cyclization, intermolecular hydrogen transfer, and hydration. As a multifunctional catalyst, TFA mediated the processes efficiently and cleanly.

  DOI：

  10.1021/jo7015604

文献信息

• TFA-Mediated Tandem Friedel−Crafts Alkylation/Cyclization/Hydrogen Transfer Process for the Synthesis of Flavylium Compounds
  作者：Yan-Chao Wu、Li Liu、Yu-Liang Liu、Dong Wang、Yong-Jun Chen

  DOI：10.1021/jo7015604

  日期：2007.11.1

  [Graphics]The tandem reaction of phenols and chalcones in refluxing TFA gave the flavylium species of 2-hydroxy-2-phenyl-2H-chromenes in moderate to good isolated yields. The reaction was proposed to involve a tandem transformation of Friedel-Crafts alkylation, dehydrative cyclization, intermolecular hydrogen transfer, and hydration. As a multifunctional catalyst, TFA mediated the processes efficiently and cleanly.