[2-amino-6-(1-ethanesulfonyl-piperidin-4-ylamino)-pyridin-3-yl]-(5-fluoro-2-methoxy-phenyl)-methanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [2-amino-6-(1-ethanesulfonyl-piperidin-4-ylamino)-pyridin-3-yl]-(5-fluoro-2-methoxy-phenyl)-methanone
• 英文别名: [2-amino-6-[(1-ethylsulfonylpiperidin-4-yl)amino]pyridin-3-yl]-(5-fluoro-2-methoxyphenyl)methanone
• 化学式: C₂₀H₂₅FN₄O₄S
• 分子量: 436.507
• InChiKey: NMOHBYKZMKXTEG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  123
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  [4-amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone trifluoroacetic acid salt 、 乙基磺酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以63%的产率得到[2-amino-6-(1-ethanesulfonyl-piperidin-4-ylamino)-pyridin-3-yl]-(5-fluoro-2-methoxy-phenyl)-methanone
  参考文献：
  名称：

  2,6-Diaminopyridine derivatives

  摘要：

  本发明涉及一种新型2,6-二氨基吡啶衍生物，其化学式如下，其中R1和R2的定义如下，这些化合物能够抑制细胞周期依赖的激酶。这些化合物及其药学上可接受的盐和酯具有抗增殖活性，并可用于治疗或控制癌症，尤其是固体肿瘤。本发明还涉及含有这些化合物的药物组合物以及治疗或控制癌症的方法，尤其是治疗或控制乳腺、肺、结肠和前列腺肿瘤。还公开了在制备这些新型2,6-二氨基吡啶衍生物中有用的中间体。

  公开号：

  US20060014708A1

文献信息

• 2,6-diaminopyridine derivatives
  申请人：Hoffmann-La Roche Inc.

  公开号：US07423051B2

  公开（公告）日：2008-09-09

  Novel 2,6-diaminopyridine derivatives of formula wherein R1 and R2 are as defined below, are disclosed. These compounds inhibit cyclin-dependent kinases. These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung, colon and prostate tumors. Also disclosed are intermediates useful in the preparation of these novel 2,6-diaminopyridine derivatives.

  本发明揭示了公式中R1和R2如下所定义的新颖2,6-二氨基吡啶衍生物。这些化合物抑制细胞周期依赖性激酶。这些化合物及其药学上可接受的盐和酯具有抗增殖活性，并可用于治疗或控制癌症，尤其是实体肿瘤。本发明还涉及含有这些化合物的制药组合物以及治疗或控制癌症的方法，尤其是乳腺癌、肺癌、结肠癌和前列腺肿瘤的治疗或控制。还揭示了在制备这些新颖的2,6-二氨基吡啶衍生物中有用的中间体。
• NOVEL 2,6-DIAMINOPYRIDINE-3-ONE DERIVATIVES
  申请人：F. Hoffmann-Roche AG

  公开号：EP1771420A1

  公开（公告）日：2007-04-11
• US7423051B2
  申请人：——

  公开号：US7423051B2

  公开（公告）日：2008-09-09
• [EN] NOVEL 2,6-DIAMINOPYRIDINE-3-ONE DERIVATIVES<br/>[FR] NOUVEAUX DERIVES DE 2,6-DIAMINOPYRIDINE-3-ONE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2006005548A1

  公开（公告）日：2006-01-19

  Novel 2,6-diaminopyridine derivatives of formula (I) wherein R1 and R2 are as defined below, are disclosed. These compounds inhibit cyclin-dependent kinases. These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast lung, colon and prostate tumors. Also disclosed are intermediates useful in the preparation of these novel 2,6-diaminopyridine derivatives.
• 2,6-Diaminopyridine derivatives
  申请人：Bartkovitz Joseph David

  公开号：US20060014708A1

  公开（公告）日：2006-01-19

  Novel 2,6-diaminopyridine derivatives of formula wherein R 1 and R 2 are as defined below, are disclosed. These compounds inhibit cyclin-dependent kinases. These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung, colon and prostate tumors. Also disclosed are intermediates useful in the preparation of these novel 2,6-diaminopyridine derivatives.

  本发明涉及一种新型2,6-二氨基吡啶衍生物，其化学式如下，其中R1和R2的定义如下，这些化合物能够抑制细胞周期依赖的激酶。这些化合物及其药学上可接受的盐和酯具有抗增殖活性，并可用于治疗或控制癌症，尤其是固体肿瘤。本发明还涉及含有这些化合物的药物组合物以及治疗或控制癌症的方法，尤其是治疗或控制乳腺、肺、结肠和前列腺肿瘤。还公开了在制备这些新型2,6-二氨基吡啶衍生物中有用的中间体。