methanesulfonic acid 2-[2-(2-ethoxy-ethoxy)-ethoxy]-ethyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: methanesulfonic acid 2-[2-(2-ethoxy-ethoxy)-ethoxy]-ethyl ester
• 英文别名: 2-(2-(2-ethoxyethoxy)ethoxy)ethyl mesylate；2-[2-(2-Ethoxyethoxy)ethoxy]ethyl methanesulfonate；2-[2-(2-ethoxyethoxy)ethoxy]ethyl methanesulfonate
• 化学式: C₉H₂₀O₆S
• 分子量: 256.32
• InChiKey: VGBPBFDTLLBFAO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  16
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  79.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  methanesulfonic acid 2-[2-(2-ethoxy-ethoxy)-ethoxy]-ethyl ester 在 lithium aluminium tetrahydride 、 caesium carbonate 作用下， 以 四氢呋喃 、 丙酮 为溶剂， 反应 1.0h， 生成 (2,5-bis-{2-[2-(2-ethoxy-ethoxy)-ethoxy]-ethoxy}-4-hydroxymethyl-phenyl)-methanol
  参考文献：
  名称：

  Binding of Tetramethylammonium to Polyether Side-Chained Aromatic Hosts. Evaluation of the Binding Contribution from Ether Oxygen Donors

  摘要：

  A set of macrocyclic and open-chain aromatic ligands endowed with polyether side chains has been prepared to assess the contribution of ether oxygen donors to the binding of tetramethylammonium (TMA), a cation believed incapable of interacting with oxygen donors. The open-chain hosts consisted of an aromatic binding site and side chains possessing a variable number of ether oxygen donors; the macrocyclic ligands were based on the structure of a previously investigated host, the dimeric cyclophane 1,4-xylylene-1,4-phenylene diacetate (DXPDA), implemented with polyether-type side chains in the backbone. Association to tetramethylammonium picrate (TMAP) was measured in CDCl3 at T = 296 K by H-1 NMR titrations. Results confirm that the main contribution to the binding of TMA comes from the cation-pi interaction established with the aromatic binding sites, but they unequivocally show that polyether chains participate with cooperative contributions, although of markedly smaller entity. Water is also bound, but the two guests interact with aromatic rings and oxygen donors in an essentially noncompetitive way. An improved procedure for the preparation of cyclophanic tetraester derivatives has been developed that conveniently recycles the oligomeric ester byproducts formed in the one-pot cyclization reaction. An alternative entry to benzylic diketones has also been provided that makes use of a low-order cyanocuprate reagent to prepare in fair yields a class of compounds otherwise uneasily accessible.

  DOI：

  10.1021/jo034905h
• 作为产物：
  描述：

  三乙二醇乙醚 、 甲基磺酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 17.5h， 生成 methanesulfonic acid 2-[2-(2-ethoxy-ethoxy)-ethoxy]-ethyl ester
  参考文献：
  名称：

  聚乙二醇（PEG）链官能化的3-羟基-4-吡啶酮螯合剂的合成与表征，旨在顺序注入天然水中的铁

  摘要：

  成功实现了高度亲水性3-羟基-4-吡啶酮配体的合成，该配体已被亲水性乙二醇链（PEG-HPO）官能化，并已与其铁（III）配合物一起报道。聚乙二醇化的3,4-HPO配体及其铁（III）配合物的亲水性得到了改善，已在分析应用中进行了全面研究，该新型螯合剂可用于分光光度法连续进样测定水中的铁。与N-烷基-3-羟基-4-吡啶酮配体相比，新的配体提供了更好的灵敏度和更低的铁测定LOD。发达的顺序进样方法的动态工作范围为0.10–1.00 mg Fe / L，LOD为48μg/ L。由于使用了顺序喷射系统，因此废水总产量<3，0.92毫克的HNO 3和样品的500微升。评估了两个参考样品的准确性，得出相对偏差<5％。分析了八个水域样品，并将结果与​​参考程序进行了比较，两组结果均未观察到统计学差异。

  DOI：

  10.1016/j.poly.2015.09.015

文献信息

• [EN] THERAPEUTIC AGENT FOR TREATING TUMORS<br/>[FR] AGENT THÉRAPEUTIQUE POUR LE TRAITEMENT DE TUMEURS
  申请人：UNIV NEW YORK STATE RES FOUND

  公开号：WO2015143092A1

  公开（公告）日：2015-09-24

  The present disclosure relates to a therapeutic agent of the formula: Z-C(=O)-(CH2)n-ϕ-S-S-(CRR')m-(CH2)p-C(=O)- NH-(CH2)q-NH-Y[NH-(CH2)r-X-T-W][NH-(CH2-CH-O)t (CH2)s-NH-V] Formula I or a pharmaceutically acceptable salt thereof, useful for treating tumors, including cancers. Where the compound of Formula I also contains a radionuclide or an imaging agent or both, the compound of formula I is a theranostic agent useful for treating and diagnosing tumors, including cancers.

  本公开涉及一种治疗剂，其化学式为：Z-C(=O)-(CH2)n-ϕ-S-S-(CRR')m-(CH2)p-C(=O)- NH-(CH2)q-NH-Y[NH-(CH2)r-X-T-W][NH-(CH2-CH-O)t (CH2)s-NH-V] 化学式I或其药学上可接受的盐，用于治疗肿瘤，包括癌症。化合物I的化学式还包含放射性核素或成像剂或两者的情况下，化合物I是一种治疗和诊断肿瘤，包括癌症的治疗剂。
• [EN] α-TRUXILLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF<br/>[FR] DÉRIVÉS D'ACIDE Α-TRUXILLIQUE ET COMPOSITIONS PHARMACEUTIQUES ASSOCIÉES
  申请人：UNIV NEW YORK STATE RES FOUND

  公开号：WO2017156354A1

  公开（公告）日：2017-09-14

  The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, said compound having the structure : Formula (I)

  本发明提供了一种化合物，以及一种抑制脂肪酸结合蛋白（FABP）活性的方法，包括将该化合物与FABP接触，所述化合物具有结构：Formula (I)。
• GALACTOSE DERIVATIVE, DRUG CARRIER AND MEDICINAL COMPOSITION
  申请人：Nippon Shinyaku Co., Ltd.

  公开号：EP1783137A1

  公开（公告）日：2007-05-09

  The object of the invention is to provide a novel and useful galactose derivative constituting a drug carrier by which a medicine can be efficiently transferred into the liver, a drug carrier comprising the derivative, and a pharmaceutical composition comprising the carrier and a medicine. The present invention relates to a galactose derivative made up of galactose, a suitable spacer and a certain lipid, a drug carrier comprising the derivative and a cationic lipid, and a pharmaceutical composition comprising the carrier and a medicine (preferably a double strand RNA, a double strand DNA, an oligo nucleic acid) .

  本发明的目的是提供一种新颖而有用的半乳糖衍生物，它构成一种药物载体，通过它可以将药物有效地转移到肝脏中；提供一种由该衍生物组成的药物载体；提供一种由该载体和药物组成的药物组合物。 本发明涉及一种由半乳糖、适当的间隔物和某种脂质组成的半乳糖衍生物，一种由该衍生物和阳离子脂质组成的药物载体，以及一种由该载体和药物（最好是双链 RNA、双链 DNA、寡核酸）组成的药物组合物。
• US9228063B2
  申请人：——

  公开号：US9228063B2

  公开（公告）日：2016-01-05
• Binding of Tetramethylammonium to Polyether Side-Chained Aromatic Hosts. Evaluation of the Binding Contribution from Ether Oxygen Donors
  作者：Sandra Bartoli、Gina De Nicola、Stefano Roelens

  DOI：10.1021/jo034905h

  日期：2003.10.1

  A set of macrocyclic and open-chain aromatic ligands endowed with polyether side chains has been prepared to assess the contribution of ether oxygen donors to the binding of tetramethylammonium (TMA), a cation believed incapable of interacting with oxygen donors. The open-chain hosts consisted of an aromatic binding site and side chains possessing a variable number of ether oxygen donors; the macrocyclic ligands were based on the structure of a previously investigated host, the dimeric cyclophane 1,4-xylylene-1,4-phenylene diacetate (DXPDA), implemented with polyether-type side chains in the backbone. Association to tetramethylammonium picrate (TMAP) was measured in CDCl3 at T = 296 K by H-1 NMR titrations. Results confirm that the main contribution to the binding of TMA comes from the cation-pi interaction established with the aromatic binding sites, but they unequivocally show that polyether chains participate with cooperative contributions, although of markedly smaller entity. Water is also bound, but the two guests interact with aromatic rings and oxygen donors in an essentially noncompetitive way. An improved procedure for the preparation of cyclophanic tetraester derivatives has been developed that conveniently recycles the oligomeric ester byproducts formed in the one-pot cyclization reaction. An alternative entry to benzylic diketones has also been provided that makes use of a low-order cyanocuprate reagent to prepare in fair yields a class of compounds otherwise uneasily accessible.