N-(4-fluorobenzyl)-1H-indole-2-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-(4-fluorobenzyl)-1H-indole-2-carboxamide
• 英文别名: N-[(4-fluorophenyl)methyl]-1H-indole-2-carboxamide
• 化学式: C₁₆H₁₃FN₂O
• 分子量: 268.29
• InChiKey: YFMHWFACMVIWAO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  44.9
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  对甲基苯甲酰氯 、 N-(4-fluorobenzyl)-1H-indole-2-carboxamide 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 以56%的产率得到1-(4-Methyl-benzoyl)-1H-indole-2-carboxylic acid 4-fluoro-benzylamide
  参考文献：
  名称：

  Synthesis and Antioxidant Properties of Novel N-Substituted Indole-2-carboxamide and Indole-3-acetamide Derivatives

  摘要：

  A series of N-substituted indole-2-carboxamide and indole-3-acetamide derivatives have been prepared and their in vitro effects on rat liver lipid peroxidation levels and superoxide anion formation were determined. The results clearly demonstrate that indole derivatives 4, 5,10,15,17 are very efficient antioxidants compared to (X-tocopherol.

  DOI：

  10.1002/1521-4184(200209)335:7<331::aid-ardp331>3.0.co;2-7
• 作为产物：
  描述：

  吲哚-2-羧酸 、 对氟苄胺 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 以57%的产率得到N-(4-fluorobenzyl)-1H-indole-2-carboxamide
  参考文献：
  名称：

  Synthesis and Antioxidant Properties of Novel N-Substituted Indole-2-carboxamide and Indole-3-acetamide Derivatives

  摘要：

  A series of N-substituted indole-2-carboxamide and indole-3-acetamide derivatives have been prepared and their in vitro effects on rat liver lipid peroxidation levels and superoxide anion formation were determined. The results clearly demonstrate that indole derivatives 4, 5,10,15,17 are very efficient antioxidants compared to (X-tocopherol.

  DOI：

  10.1002/1521-4184(200209)335:7<331::aid-ardp331>3.0.co;2-7

文献信息

• Indole derivatives useful for the treatment of diseases
  申请人：Pfizer Limited

  公开号：EP1440966A1

  公开（公告）日：2004-07-28

  The invention relates to indole derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The indole derivatives according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.

  本发明涉及吲哚衍生物及其制备过程、制备过程中使用的中间体、含有此类衍生物的组合物及其用途。根据本发明的吲哚衍生物可用于多种疾病、失调和病症，特别是炎症、过敏和呼吸系统疾病、失调和病症。
• Synthesis and Antioxidant Properties of Novel N-Substituted Indole-2-carboxamide and Indole-3-acetamide Derivatives
  作者：Süreyya Ölgen、Tülay Çoban

  DOI：10.1002/1521-4184(200209)335:7<331::aid-ardp331>3.0.co;2-7

  日期：2002.9

  A series of N-substituted indole-2-carboxamide and indole-3-acetamide derivatives have been prepared and their in vitro effects on rat liver lipid peroxidation levels and superoxide anion formation were determined. The results clearly demonstrate that indole derivatives 4, 5,10,15,17 are very efficient antioxidants compared to (X-tocopherol.