The Mukaiyama–Michael addition of a β,β-dimethyl substituted silyl ketene acetal to α,β-unsaturated ketones using tetra-n-butylammonium bibenzoate as a nucleophilic catalyst
作者:Rudhramyna Gnaneshwar、Prakash P. Wadgaonkar、Swaminathan Sivaram
DOI:10.1016/s0040-4039(03)01511-9
日期:2003.8
The Michael addition of a β,β-dimethyl substituted silyl ketene acetal [Me2CC(OMe)OSiMe3] to α,β-unsaturated ketones, namely, 2-cyclopentenone, 2-cyclohexenone, 3-methyl-2-cyclohexenone, isophorone, methyl vinyl ketone and mesityl oxide occurs smoothly in the presence of the nucleophilic catalyst, tetra-n-butyl ammonium bibenzoate (TBABB) in THF giving the corresponding 1,4-adducts in excellent yields
迈克尔加成一个β的,β -二甲基取代的甲硅烷烯酮缩醛[我2 CC(OME)OSiMe 3 ]α,β不饱和酮,即,2-环戊烯酮,2-环己烯酮,3-甲基-2-环己烯酮,异佛尔酮,甲基乙烯基酮和异丁烯酰氧化物在亲核催化剂,四正丁基联苯甲酸四正铵铵(TBABB)在THF中的存在下平稳生成,从而以优异的收率得到相应的1,4-加合物。