diethyl 1-fluoro-2-(2,4-dichlorophenyl)-2-oxoethylphosphonate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: diethyl 1-fluoro-2-(2,4-dichlorophenyl)-2-oxoethylphosphonate
• 英文别名: 1-(2,4-Dichlorophenyl)-2-diethoxyphosphoryl-2-fluoroethanone
• 化学式: C₁₂H₁₄Cl₂FO₄P
• 分子量: 343.119
• InChiKey: ITIBCAXAZXXZCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-二乙基膦酰基-2-氟乙酸 在 三乙胺 、 magnesium chloride 作用下， 以 甲苯 为溶剂， 反应 7.0h， 生成 diethyl 1-fluoro-2-(2,4-dichlorophenyl)-2-oxoethylphosphonate
  参考文献：
  名称：

  Acylation of α-fluorophosphonoacetate derivatives using magnesium chloride-triethylamine

  摘要：

  Acylation of alpha-fluorophosphonoacetate derivatives in the presence of magnesium chloride-triethylamine has been described. Acylations of triethyl alpha-fluorophosphonoacetate 1 and diethyl alpha-fluorophosphonoacetic acid 7 were proceeded under mild conditions to provide alpha-fluoro-beta-keto esters 3 and alpha-fluoro-beta-keto phosphonates 9, respectively, in high yields. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00807-8

文献信息

• Synthesis of α-Fluoro-β-keto Phosphonates from α-Fluoro Phosphonoacetatic Acid
  作者：Dae Young Kim、Young Jae Choi

  DOI：10.1080/00397919808006848

  日期：1998.4

  Abstract A new synthesis of α-fluoro-β-keto phosphonates, via acylation reaction of α-fluoro phosphonoacetate dianion with carboxylic acid chlorides followed by decarboxylation, is described.

  摘要 描述了通过 α-氟膦酰基乙酸酯二阴离子与羧酸氯化物的酰化反应，然后脱羧，合成 α-氟代-β-酮膦酸酯的新方法。
• Acylation of α-fluorophosphonoacetate derivatives using magnesium chloride-triethylamine
  作者：Dae Young Kim、Yong Mi Lee、Young Jae Choi

  DOI：10.1016/s0040-4020(99)00807-8

  日期：1999.11

  Acylation of alpha-fluorophosphonoacetate derivatives in the presence of magnesium chloride-triethylamine has been described. Acylations of triethyl alpha-fluorophosphonoacetate 1 and diethyl alpha-fluorophosphonoacetic acid 7 were proceeded under mild conditions to provide alpha-fluoro-beta-keto esters 3 and alpha-fluoro-beta-keto phosphonates 9, respectively, in high yields. (C) 1999 Elsevier Science Ltd. All rights reserved.