2-(4-fluorophenyl)-6-(4-hydroxyphenylsulfanyl)imidazo[1,2-a]pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4-fluorophenyl)-6-(4-hydroxyphenylsulfanyl)imidazo[1,2-a]pyridine
• 英文别名: 4-[2-(4-Fluorophenyl)imidazo[1,2-a]pyridin-6-yl]sulfanylphenol
• 化学式: C₁₉H₁₃FN₂OS
• 分子量: 336.389
• InChiKey: LMQJRLBVFNWZHS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  62.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-羟基苯硫酚 、 6-iodo-2-(4-fluorophenyl)imidazo[1,2-a]pyridine 在 copper(l) iodide 、 potassium carbonate 、 乙二醇 作用下， 以 异丙醇 为溶剂， 反应 20.0h， 以96%的产率得到2-(4-fluorophenyl)-6-(4-hydroxyphenylsulfanyl)imidazo[1,2-a]pyridine
  参考文献：
  名称：

  A general and efficient method for the copper-catalyzed cross-coupling of amides and thiophenols with 6-halogenoimidazo[1,2-a]pyridines

  摘要：

  Convenient and efficient methods for the preparation of novel 6-amido and 6-phenylsulfanylimidazo[1,2-a]pyridine derivatives that utilize copper-catalyzed methodologies are reported. These methods are particularly noteworthy because of their experimental simplicity and the low cost of the catalyst system. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.04.007

文献信息

• A general and efficient method for the copper-catalyzed cross-coupling of amides and thiophenols with 6-halogenoimidazo[1,2-a]pyridines
  作者：Cécile Enguehard-Gueiffier、Isabelle Thery、Alain Gueiffier、Stephen L. Buchwald

  DOI：10.1016/j.tet.2006.04.007

  日期：2006.6

  Convenient and efficient methods for the preparation of novel 6-amido and 6-phenylsulfanylimidazo[1,2-a]pyridine derivatives that utilize copper-catalyzed methodologies are reported. These methods are particularly noteworthy because of their experimental simplicity and the low cost of the catalyst system. (c) 2006 Elsevier Ltd. All rights reserved.