N-Sulfo-Alpha-D-Glucosamine | 130263-96-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-Sulfo-Alpha-D-Glucosamine
• 英文别名: [(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]sulfamic acid
• CAS: 130263-96-6
• 化学式: C₆H₁₃NO₈S
• 分子量: 259.24
• InChiKey: PRDZVHCOEWJPOB-UKFBFLRUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  165
• 氢给体数：
  6
• 氢受体数：
  9

文献信息

• [EN] HEPARAN SULFATE GLYCOMIMETIC COMPOUNDS AND THEIR PHARMACEUTICAL AND COSMECEUTICAL USES<br/>[FR] COMPOSÉS GLYCOMIMÉTIQUES DE SULFATE D'HÉPARANE ET LEURS UTILISATIONS PHARMACEUTIQUES ET COSMÉTIQUES
  申请人：VICTORIA LINK LTD

  公开号：WO2018174725A1

  公开（公告）日：2018-09-27

  The invention relates to dendritic compounds, the use of these compounds as pharmaceuticals, pharmaceutical and cosmeceutical compositions containing the compounds, and methods of treating cancer, inflammation, diabetic nephropathy, neurodegenerative disorders, Niemann-Pick Type C disease, or dermatological conditions.

  该发明涉及树枝状化合物，这些化合物作为药物的使用，包含这些化合物的药物和美容药物组合物，以及治疗癌症、炎症、糖尿病肾病、神经退行性疾病、尼曼-皮克病C型或皮肤病学状况的方法。
• Method for quantitatively determining specific groups constituting heparins or low molecular wieght heparins using HPLC
  申请人：Aventis Pharma S.A.

  公开号：EP1580197A1

  公开（公告）日：2005-09-28

  A method for analysing heparins or low-molecular-weight heparins, characterized in that the sample to be assayed is depolymerized by the action of heparinases and then, where appropriate, the depolymerizate obtained is reduced and then an analysis is carried out by high performance liquid chromatography.

  一种分析肝素或低分子量肝素的方法，其特征在于待测样品在肝素酶的作用下解聚，然后在适当的情况下还原解聚物，再用高效液相色谱法进行分析。
• Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products
  申请人：Aventis Pharma S.A.

  公开号：EP1582531A1

  公开（公告）日：2005-10-05

  The invention provides a process for preparing heparin products with a reduced content of glycoserine. A method for detecting glycoserine in preparations of heparin is also provided.

  本发明提供了一种制备甘丝氨酸含量降低的肝素产品的工艺。本发明还提供了一种检测肝素制剂中甘丝氨酸含量的方法。
• Method for detection and quantification of glycoserine in a sample of heparin or heparin products
  申请人：Aventis Pharma S.A.

  公开号：EP2314631A2

  公开（公告）日：2011-04-27

  The invention relates to a process for oxidizing unfractionated heparins, and to a method for determining the glycoserine content of a sample of a heparin or a heparin product, comprising depolymerizing the sample with at least one heparinase and analyzing the sample using a chromatography process to detect the presence or absence of glycoserine and/or oxidized glycoserine residues in the sample, wherein said chromatography process detects acetylated groups.

  本发明涉及一种氧化未分馏肝素的工艺，以及一种确定肝素或肝素产品样品中糖丝氨酸含量的方法，包括用至少一种肝素酶解聚样品，并使用层析工艺分析样品，以检测样品中是否存在糖丝氨酸和/或氧化的糖丝氨酸残基，其中所述层析工艺检测乙酰化基团。
• Oligosaccharidic compounds derived from heparin
  申请人：Aventis Pharma S.A.

  公开号：EP2314632A2

  公开（公告）日：2011-04-27

  The invention relates to a process for oxidizing unfractionated heparins, to a method for determining the glycoserine content of a sample of a heparin or a heparin product, comprising depolymerizing the sample with at least one heparinase and analyzing the sample using a chromatography process to detect the presence or absence of glycoserine and/or oxidized glycoserine residues in the sample, as well as to oligosaccharidic compounds obtained by this process.

  本发明涉及一种氧化未分馏肝素的工艺，涉及一种确定肝素或肝素产品样品中糖丝氨酸含量的方法，该方法包括用至少一种肝素酶解聚样品，并用色谱法分析样品，以检测样品中是否存在糖丝氨酸和/或氧化的糖丝氨酸残基，还涉及通过该工艺获得的低聚糖化合物。