methyl 2-(2-(4-chlorophenyl)-4-oxoquinazolin-3(4H)-yl)acetate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 2-(2-(4-chlorophenyl)-4-oxoquinazolin-3(4H)-yl)acetate
• 英文别名: Methyl 2-[2-(4-chlorophenyl)-4-oxoquinazolin-3-yl]acetate
• 化学式: C₁₇H₁₃ClN₂O₃
• 分子量: 328.755
• InChiKey: OXAAXQQGCMCLDQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  59
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-氯苯甲醛 、 邻氨基苯甲酸 、 甘胺酸甲酯 在 1-丙基磷酸酐 、 三乙胺 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 乙酸乙酯 为溶剂， 反应 5.0h， 以86%的产率得到methyl 2-(2-(4-chlorophenyl)-4-oxoquinazolin-3(4H)-yl)acetate
  参考文献：
  名称：

  T3P catalyzed one pot three-component synthesis of 2,3-disubstituted 3H-quinazolin-4-ones

  摘要：

  An efficient methodology for the synthesis of 2,3-disubstituted 3H-quinazolin-4-ones is described via one-pot three component reaction from anthranilic acid using T3P as catalyst. Mild reaction conditions, short reaction time, broad functional group tolerance, easy isolation of products and good yields are main advantages of this protocol. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.cclet.2015.03.037

文献信息

• T3P catalyzed one pot three-component synthesis of 2,3-disubstituted 3H-quinazolin-4-ones
  作者：Goravanahalli M. Raghavendra、Chottanahalli S. Pavan Kumar、Gejjalagere P. Suresha、Kanchugarakoppal S. Rangappa、Kempegowda Mantelingu

  DOI：10.1016/j.cclet.2015.03.037

  日期：2015.8

  An efficient methodology for the synthesis of 2,3-disubstituted 3H-quinazolin-4-ones is described via one-pot three component reaction from anthranilic acid using T3P as catalyst. Mild reaction conditions, short reaction time, broad functional group tolerance, easy isolation of products and good yields are main advantages of this protocol. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.