(2S)-2-amino-1-(1,3-oxazol-2-yl)propan-1-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S)-2-amino-1-(1,3-oxazol-2-yl)propan-1-one
• 化学式: C₆H₈N₂O₂
• 分子量: 140.14
• InChiKey: VDZJIICRIPDGTC-BYPYZUCNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  69.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• LINEAR PEPTIDE ANTIBIOTCS
  申请人：RQX PHARMACEUTICALS, INC.

  公开号：US20160194358A1

  公开（公告）日：2016-07-07

  Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases) and in other embodiments provide for a broad spectrum of antibiotic bioactivity. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

  本文提供了一些抗菌化合物，其中在某些实施例中，这些化合物具有广谱生物活性。在其他实施例中，这些化合物可以克服细菌信号肽酶（SPases）定义位置上的单个氨基酸突变所带来的耐药性，并提供广谱抗生素生物活性。还提供了使用所述化合物的制药组合物和治疗方法。
• Macrocyclic broad spectrum antibiotics
  申请人：RQX PHARMACEUTICALS, INC.

  公开号：US10392422B2

  公开（公告）日：2019-08-27

  Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

  本文提供的是抗菌化合物，其中的化合物在某些实施方案中具有广谱生物活性。在不同的实施方案中，这些化合物通过抑制细菌 1 型信号肽酶（SpsB）发挥作用，SpsB 是细菌中的一种重要蛋白质。还提供了使用本文所述化合物进行治疗的药物组合物和方法。
• LINEAR PEPTIDE ANTIBIOTICS
  申请人：RQX Pharmaceuticals, Inc.

  公开号：EP3033352A1

  公开（公告）日：2016-06-22
• MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS
  申请人：RQX Pharmaceuticals, Inc.

  公开号：EP3145944A2

  公开（公告）日：2017-03-29
• [EN] LINEAR PEPTIDE ANTIBIOTCS<br/>[FR] ANTIBIOTIQUES À BASE DE PEPTIDES LINÉAIRES
  申请人：RQX PHARMACEUTICALS INC

  公开号：WO2015023898A1

  公开（公告）日：2015-02-19

  Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases) and in other embodiments provide for a broad spectrum of antibiotic bioactivity. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.