2-(3,4-dihydro-6,7-dimethoxy-2(1 H)-isoquinolinyl)-1-[1-methyl-5-[4-(methylthio)benzoyl]-1H-pyrrol-3-yl]-ethanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(3,4-dihydro-6,7-dimethoxy-2(1 H)-isoquinolinyl)-1-[1-methyl-5-[4-(methylthio)benzoyl]-1H-pyrrol-3-yl]-ethanone
• 英文别名: 2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-1-[1-methyl-5-(4-methylsulfanylbenzoyl)pyrrol-3-yl]ethanone
• 化学式: C₂₆H₂₈N₂O₄S
• 分子量: 464.585
• InChiKey: CFOKVGPEXKOFFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  86.1
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Isoindolyl and isoquinolinyl aroyl pyrrole compounds
  申请人：——

  公开号：US20020128286A1

  公开（公告）日：2002-09-12

  This invention is directed to isoindolyl and isoquinolinyl aroyl pyrrole compounds pharmaceutically useful as agents or modulators for the treatment of central nervous system disorders and methods for the treatment of central nervous system disorders.

  本发明涉及对于中枢神经系统疾病治疗的代理或调节剂而言具有药用价值的异吲哚基和异喹啉基芳酰吡咯化合物，以及用于治疗中枢神经系统疾病的方法。
• ISOINDOLYL AND ISOQUINOLINYL AROYL PYRROLE COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS
  申请人：Ortho-McNeil Pharmaceutical, Inc.

  公开号：EP1351950A2

  公开（公告）日：2003-10-15
• ISOQUINOLINYL AROYL PYRROLE COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS
  申请人：Ortho-McNeil Pharmaceutical, Inc.

  公开号：EP1351950B1

  公开（公告）日：2007-08-08
• US6492387B2
  申请人：——

  公开号：US6492387B2

  公开（公告）日：2002-12-10
• [EN] ISOINDOLYL AND ISOQUINOLINYL AROYL PYRROLE COMPOUNDS<br/>[FR] COMPOSES D'ISOINDOLYLE ET D'ISOQUINOLINYL AROYL PYRROLE
  申请人：ORTHO MCNEIL PHARM INC

  公开号：WO2002057253A2

  公开（公告）日：2002-07-25

  This invention is directed to isoindolyl and isoquinolinyl aroyl pyrrole compounds pharmaceutically useful as agents or modulators for the treatment of central nervous system disorders and methods for the treatment of central nervous system disorders.