3-(5-Methoxythiophen-2-yl)butanal

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(5-Methoxythiophen-2-yl)butanal
• 化学式: C₉H₁₂O₂S
• 分子量: 184.26
• InChiKey: DUBNIOOOEHTFDQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  54.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Enantioselective transformation of alpha, beta-unsaturated aldehydes using chiral organic catalysts
  申请人：——

  公开号：US20030109718A1

  公开（公告）日：2003-06-12

  Nonmetallic organic catalysts are provided that facilitate the enantioselective reaction of &agr;,&bgr;-unsaturated aldehydes. The catalysts are chiral imidazolidinone compounds having the structure of formula (IIA) or (IIB) 1 or are acid addition salts thereof, wherein, in one preferred embodiment, R 1 is C 1 -C 6 alkyl, R 2 is tri(C 1 -C 6 alkyl)-substituted methyl, R 3 and R 4 are hydrogen, and R 5 is phenyl optionally substituted with 1 or 2 substituents selected from the group consisting of halo, hydroxyl, and C 1 -C 6 alkyl. The chiral imidazolidinones are useful in catalyzing a wide variety of reactions, including cycloaddition reactions, Friedel-Crafts alkylation reactions, and Michael additions.

  提供了非金属有机催化剂，促进α，β-不饱和醛的对映选择性反应。该催化剂是手性咪唑啉酮化合物，具有式（IIA）或（IIB）1的结构，或其酸加成盐，其中，在一种优选实施例中，R1为C1-C6烷基，R2为三（C1-C6烷基）取代的甲基，R3和R4为氢，R5为苯基，可选择地取代1或2个来自卤素、羟基和C1-C6烷基的取代基。手性咪唑啉酮在催化各种反应方面有用，包括环加成反应、Friedel-Crafts烷基化反应和Michael加成反应。
• ENANTIOSELECTIVE TRANSFORMATION OF $g(a), $g(b)-UNSATURATED ALDEHYDES USING CHIRAL ORGANIC CATALYSTS
  申请人：CALIFORNIA INSTITUTE OF TECHNOLOGY

  公开号：EP1412335A2

  公开（公告）日：2004-04-28
• EP1412335A4
  申请人：——

  公开号：EP1412335A4

  公开（公告）日：2004-11-17
• US6784323B2
  申请人：——

  公开号：US6784323B2

  公开（公告）日：2004-08-31
• [EN] ENANTIOSELECTIVE TRANSFORMATION OF alpha , beta -UNSATURATED ALDEHYDES USING CHIRAL ORGANIC CATALYSTS<br/>[FR] TRANSFORMATION ENANTIOSELECTIVE D'ALDEHYDES DOLLAR G(A), DOLLAR G(B)-INSATURES A L'AIDE DE CATALYSEURS ORGANIQUES CHIRAUX
  申请人：CALIFORNIA INST OF TECHN

  公开号：WO2003002491A2

  公开（公告）日：2003-01-09

  Nonmetallic organic catalysts are provided that facilitate the enantioselective reaction of α, β-unsaturated aldehydes. The catalysts are chiral imidazolidinone compounds having the structure of formula (IIA) or (IIB) or are acid addition salts thereof, wherein, in one preferred embodiment, R1 is C1-C6 alkyl, R2 is tri(C¿1?-C6 alkyl)substituted methyl, R?3 and R4¿ are hydrogen, and R5 is phenyl optionally substituted with one 1 or 2 substituents selected from the group consisting of halo, hydroxyl, and C¿1?-C6 alkyl. The chiral imidazolidinones are useful in catalyzing a wide variety of reactions, including cycloaddition reactions, Friedel-Crafts alkylation reactions, and Michael additions.