2-Amino-8-(oxiran-2-yl)-8-oxooctanal

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Amino-8-(oxiran-2-yl)-8-oxooctanal
• 化学式: C₁₀H₁₇NO₃
• 分子量: 199.25
• InChiKey: JFIQBUYLOGSUSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  72.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Oxabicycloheptanes and oxabicylcoheptenes, their preparation and use
  申请人：Kovach John S.

  公开号：US20090036309A1

  公开（公告）日：2009-02-05

  This invention provides compounds having the structure which may be used for the treatment of tumors.

  这项发明提供了具有该结构的化合物，可用于肿瘤治疗。
• INHIBITION OF HDAC2 TO PROMOTE MEMORY
  申请人：Tsai Li-Huei

  公开号：US20120101147A1

  公开（公告）日：2012-04-26

  The invention relates to methods and products for enhancing and improving recovery of lost memories. In particular the methods are accomplished by inhibiting HDAC2 and or selectively inhibiting HDAC1/2 or HDAC1/2/3.

  该发明涉及用于增强和改善丢失记忆恢复的方法和产品。具体来说，这些方法通过抑制HDAC2和/或选择性地抑制HDAC1/2或HDAC1/2/3来实现。
• Oligonucleotide analogues incorporating 5-aza-cytosine therein
  申请人：Phiasivongsa Pasit

  公开号：US20070072796A1

  公开（公告）日：2007-03-29

  Oligonucleotide analogues are provided that incorporate 5-aza-cytosine in the oligonucleotide sequence, e.g., in the form of 5-aza-2′-deoxycytidine (decitabine) or 5-aza-cytidine. In particular, oligonucleotide analogues rich in decitabine-deoxyguanosine islets (DpG and GpD) are provided to target the CpG islets in the human genome, especially in the promoter regions of genes susceptible to aberrant hypermethylation. Such analogues can be used for modulation of DNA methylation, such as effective inhibition of methylation of cytosine at the C-5 position. Methods for synthesizing these oligonucleotide analogues and for modulating nucleic acid methylation are provided. Also provided are phosphoramidite building blocks for synthesizing the oligonucleotide analogues, methods for synthesizing, formulating and administering these compounds or compositions to treat conditions, such as cancer and hematological disorders.

  提供了含有5-aza-胞嘧啶的寡核苷酸类似物，例如以5-aza-2'-脱氧胞嘧啶（地西他滨）或5-aza-胞嘧啶的形式出现在寡核苷酸序列中。特别地，提供了含有地西他滨-脱氧鸟嘌呤岛（DpG和GpD）的寡核苷酸类似物，以针对人类基因组中的CpG岛，特别是易于发生异常高甲基化的基因启动子区域。这样的类似物可用于调节DNA甲基化，例如有效抑制C-5位置的胞嘧啶的甲基化。提供了合成这些寡核苷酸类似物和调节核酸甲基化的方法。还提供了用于合成寡核苷酸类似物的磷酰胺酰胺建筑块，以及用于合成、制剂和给药这些化合物或组合物以治疗癌症和血液疾病等疾病的方法。
• LYOPHILIZED PHARMACEUTICAL COMPOSITIONS
  申请人：Astex Pharmaceuticals, Inc.

  公开号：US20170000738A1

  公开（公告）日：2017-01-05

  The invention provides a method of preparing a lyophilized pharmaceutical composition containing a compound described herein or a pharmaceutically-acceptable salt thereof. The process comprises dissolving the compound in a solvent comprising dimethylsulfoxide and optionally one or more co-solvents to form a solution, and then removing the solvent and any co-solvents by a freeze-drying process. Also provided by the invention are lyophilized pharmaceutical compositions and their use in medicine and in particular in the treatment of cancer.

  本发明提供了一种制备冻干药物组合物的方法，该组合物含有本文所述化合物或其药用可接受盐。该过程包括将化合物溶解在包含二甲基亚砜和可选的一种或多种共溶剂的溶剂中形成溶液，然后通过冷冻干燥过程去除溶剂和任何共溶剂。本发明还提供了冻干药物组合物及其在医学上的使用，特别是在癌症治疗中的使用。
• Oxabicycloheptanes and oxabicycloheptenes, their preparation and use
  申请人：Kovach John S.

  公开号：US20100029484A1

  公开（公告）日：2010-02-04

  This invention provides compounds having the structure which may be used for the treatment of tumors.

  这项发明提供了具有以下结构的化合物，可用于肿瘤治疗。