2-(4,5-Dimethyl-1,3-thiazol-3-ium-3-yl)-1-(4-hydroxyphenyl)ethanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(4,5-Dimethyl-1,3-thiazol-3-ium-3-yl)-1-(4-hydroxyphenyl)ethanone
• 化学式: C13H14NO2S+
• 分子量: 248.32
• InChiKey: CAAPNSBMGDFCTP-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  69.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Thiazolium compounds and treatments of disorders associated with protein aging
  申请人：——

  公开号：US20020055527A1

  公开（公告）日：2002-05-09

  A method and compositions are disclosed for, among other things, in an animal, (i) improving the elasticity or reducing wrinkles of the skin, treating (ii) diabetes or treating or preventing (iii) adverse sequelae of diabetes, (iv) kidney damage, (v) damage to blood vasculature, (vi) hypertension, (vii) retinopathy, (viii) damage to lens proteins, (ix) cataracts, (x) peripheral neuropathy, or (xi) osteoarthritis.

  披露了一种方法和组合物，用于在动物中：（一）改善皮肤弹性或减少皱纹，（二）治疗糖尿病，（三）治疗或预防糖尿病的不良后果，（四）肾脏损害，（五）血管损害，（六）高血压，（七）视网膜病变，（八）晶状体蛋白损害，（九）白内障，（十）周围神经病变，或（十一）骨关节炎。
• THIAZOLIUM COMPOUNDS AND TREATMENTS OF DISORDERS ASSOCIATED WITH PROTEIN AGING
  申请人：Alteon, Inc.

  公开号：EP1257272A1

  公开（公告）日：2002-11-20
• EP1257272A4
  申请人：——

  公开号：EP1257272A4

  公开（公告）日：2004-12-15
• US6458819B1
  申请人：——

  公开号：US6458819B1

  公开（公告）日：2002-10-01
• [EN] THIAZOLIUM COMPOUNDS AND TREATMENTS OF DISORDERS ASSOCIATED WITH PROTEIN AGING<br/>[FR] COMPOSES DE THIAZOLIUM ET TRAITEMENTS DE TROUBLES LIES AU VIEILLISSEMENT DES PROTEINES
  申请人：ALTEON INC

  公开号：WO2001062250A1

  公开（公告）日：2001-08-30

  A method and compositions are disclosed for, among other things, in an animal, (i) improving the elasticity or reducing wrinkles of the skin, treating (ii) diabetes or treating or preventing (iii) adverse sequelae of diabetes, (iv) kidney damage, (v) damage to blood vasculature, (vi) hypertension, (vii) retinophathy, (viii) damage to lens proteins, (ix) cataracts, (x) peripheral neurophaty, or (xi) osteoarthritis.