1-Ethenyl-3-(pyridine-3-carbonyl)piperidin-2-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Ethenyl-3-(pyridine-3-carbonyl)piperidin-2-one
• 化学式: C₁₃H₁₄N₂O₂
• 分子量: 230.26
• InChiKey: FRHMRICLKJJWHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  50.3
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• NOVEL INTERMEDIATE FOR PRODUCTION AND PROCESS FOR PRODUCING PYRIDINE DERIVATIVE
  申请人：TAIHO PHARMACEUTICAL CO., LTD.

  公开号：EP0787724A1

  公开（公告）日：1997-08-06

  This invention relates to: (1) a compound represented by the formula (V), its tautomer and a mixture of the same; (2) a process for producing the compound represented by the above-mentioned formula (V), its tautomer or a mixture of the same, which comprises reacting N-vinylpiperidone represented by the formula (I) with a nicotinate represented by the formula (II), wherein R represents a lower alkyl group, in the presence of a sodium alkoxide; (3) a process for producing a pyridine derivative represented by the formula (III), which comprises producing the compound represented by the formula (V), its tautomer or a mixture of the same by the process as described in the above (2), and then treating the obtained compound with an acid; and (4) a process for producing a pyridine derivative represented by the formula (IV), in which the treatment with an acid as described in the above (3) is followed by another treatment with a base. Thus, the present invention provides industrial processes for producing pyridine derivatives represented by the formulae (III) and (IV) safely, economically, easily and efficiently without using any hazardous reagents.

  本发明涉及(1) 由式(V)代表的化合物、其同分异构体和它们的混合物；(2) 生产由上述式(V)代表的化合物、其同分异构体或它们的混合物的工艺，该工艺包括在烷氧化钠存在下使由式(I)代表的N-乙烯基哌啶酮与由式(II)代表的烟酸酯(其中R代表低级烷基)反应；(3)生产式(III)代表的吡啶衍生物的工艺，该工艺包括用上述(2)所述的工艺生产式(V)代表的化合物、其同分异构体或它们的混合物，然后用酸处理所得到的化合物；和(4)生产式(IV)代表的吡啶衍生物的工艺，在该工艺中，用上述(3)所述的酸处理后，再用碱处理。因此，本发明提供了在不使用任何危险试剂的情况下，安全、经济、简便、高效地生产式（III）和式（IV）所代表的吡啶衍生物的工业工艺。
• JPH0892242A
  申请人：——

  公开号：JPH0892242A

  公开（公告）日：1996-04-09
• US5734059A
  申请人：——

  公开号：US5734059A

  公开（公告）日：1998-03-31