1-(2-methoxybenzoyl)-4-[1-(3-((6-methyl-2-pyridyl)oxy)-4-cyanobenzyl)-2-methyl-5-imidazolylmethyl]piperazine

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2-methoxybenzoyl)-4-[1-(3-((6-methyl-2-pyridyl)oxy)-4-cyanobenzyl)-2-methyl-5-imidazolylmethyl]piperazine
• 英文别名: 1-(2-methoxybenzoyl)-4-[1-(3-((6-methyl-pyridin-2-yl)oxy)-4-cyanobenzyl)-2-methyl-5-imidazolylmethyl]piperazine；4-[[5-[[4-(2-Methoxybenzoyl)piperazin-1-yl]methyl]-2-methylimidazol-1-yl]methyl]-2-(6-methylpyridin-2-yl)oxybenzonitrile
• 化学式: C₃₁H₃₂N₆O₃
• 分子量: 536.633
• InChiKey: AZIGYIRCJNYYJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  40
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  96.5
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• Inhibitors of prenyl-protein transferase
  申请人：——

  公开号：US20020052363A1

  公开（公告）日：2002-05-02

  The present invention comprises piperazine-containing compounds which inhibit prenyl-protein transferases, including farnesyl-protein transferase and geranylgeranyl-protein transferase type I. Such therapeutic compounds are useful in the treatment of cancer.

  本发明涉及含有哌嗪的化合物，其抑制预脂蛋白转移酶，包括法尼基蛋白转移酶和戊二烯基蛋白转移酶I型。这种治疗性化合物在癌症治疗中非常有用。
• [EN] INHIBITORS OF PRENYL-PROTEIN TRANSFERASE<br/>[FR] INHIBITEURS DE LA PRENYL-PROTEINE TRANSFERASE
  申请人：MERCK & CO INC

  公开号：WO2001060369A1

  公开（公告）日：2001-08-23

  The present invention comprises piperazine-containing compounds which inhibit prenyl-protein transferases, including farnesyl-protein transferase and geranylgeranyl-protein transferase type I. Such therapeutic compounds are useful in the treatment of cancer.