5-(Dimethylamino)pentane-1,2-diol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-(Dimethylamino)pentane-1,2-diol
• 化学式: C₇H₁₇NO₂
• 分子量: 147.22
• InChiKey: NGHKTBASBMSUTB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• IMPROVED AMINO LIPIDS AND METHODS FOR THE DELIVERY OF NUCLEIC ACIDS
  申请人：Arbutus Biopharma Corporation

  公开号：EP3225621A1

  公开（公告）日：2017-10-04

  The present invention provides superior compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target proteins at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

  本发明提供了向细胞输送治疗剂的优良组合物和方法。其中特别包括新型脂质和核酸-脂质颗粒，它们能有效封装核酸，并在体内将封装的核酸高效递送至细胞。本发明的组合物具有很高的效力，因此能以相对较低的剂量有效地敲除特定的靶蛋白。此外，与本领域以前已知的组合物和方法相比，本发明的组合物和方法毒性更低，治疗指数更高。
• ETHYLENICALLY UNSATURATED GROUP-CONTAINING ISOCYANATE COMPOUND AND PROCESS FOR PRODUCING THE SAME, AND REACTIVE MONOMER, REACTIVE (METH)ACRYLATE POLYMER AND ITS USE
  申请人：SHOWA DENKO KABUSHIKI KAISHA

  公开号：EP1812381A1

  公开（公告）日：2007-08-01
• Improved amino lipids and methods for the delivery of nucleic acids
  申请人：Arbutus Biopharma Corporation

  公开号：EP2743265B1

  公开（公告）日：2017-03-15
• Ethylenically Unsaturated Group-Containing Isocyanate Compound and Process for Producing the Same, and Reactive Monomer, Reactive (Meth) Acrylate Polymer and its Use
  申请人：Nozawa Kaneo

  公开号：US20080132597A1

  公开（公告）日：2008-06-05

  There are provided a novel ethylenically unsaturated group-containing isocyanate compound, a process for producing the same, and a reactive monomer produced from the isocyanate compound, a reactive polymer and its use. The ethylenically unsaturated group-containing isocyanate compound according to the present invention is represented by formula (I).
• US5925893A
  申请人：——

  公开号：US5925893A

  公开（公告）日：1999-07-20