[(5S)-2-cyclopentyl-5-hydroxy-7,7-dimethyl-4-thiophen-3-yl-6,8-dihydro-5H-quinolin-3-yl]-[4-(trifluoromethyl)phenyl]methanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(5S)-2-cyclopentyl-5-hydroxy-7,7-dimethyl-4-thiophen-3-yl-6,8-dihydro-5H-quinolin-3-yl]-[4-(trifluoromethyl)phenyl]methanone
• 化学式: C₂₈H₂₈F₃NO₂S
• 分子量: 499.6
• InChiKey: MLMAJGJPMOWEJB-NRFANRHFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  35
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  78.4
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• 4-HETEROARYL-TETRAHYDROQUINOLINES AND THEIR USE AS INHIBITORS OF THE CHOLESTERIN-ESTER TRANSFER PROTEIN
  申请人：STOLTEFUSS JURGEN

  公开号：US20070142420A1

  公开（公告）日：2007-06-21

  Hetero-tetrahydroquinolines can be prepared either by condensing correspondingly substituted hetero-tetrahydroquinoline aldehydes with the desired substituent or by reducing the corresponding keto-substituted hetero-tetrahydroquinolines, followed by introduction of the desired substituent by customary methods. The hetero-tetrahydroquinolines are suitable for use as active compounds in medicaments, in particular in medicaments for treating artheriosclerosis and dyslipidaemias.
• US7192971B2
  申请人：——

  公开号：US7192971B2

  公开（公告）日：2007-03-20