N-morpholinomethyl-isopropyl-sulfide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: N-morpholinomethyl-isopropyl-sulfide
• 英文别名: 1-Isopropylthiomethylmorpholine；4-(propan-2-ylsulfanylmethyl)morpholine
• 化学式: C₈H₁₇NOS
• 分子量: 175.295
• InChiKey: YXTBTNKSYWAUTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  37.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  双吗啉甲烷 、 异丙硫醇 在 samarium(III) chloride hexahydrate 作用下， 反应 6.0h， 以96%的产率得到N-morpholinomethyl-isopropyl-sulfide
  参考文献：
  名称：

  Synthesis of amino sulfides in the presence of rare-earth and transition metal catalysts

  摘要：

  Efficient procedures have been developed for the synthesis of amino sulfides by aminomethylation of thiols with higher geminal diamines, thiomethylation of secondary amines with N,N-dimethylaminomethyl sulfides, and decyclization of 1,3,6-oxadithiepane or N-tert-butyl-1,5,3-dithiazepane with secondary amines in the presence of rare-earth and transition metals.

  DOI：

  10.1134/s1070428012070020

文献信息

• Purinyl-N-hydroxyl pyrimidine formamide derivative, preparation methods and uses thereof
  申请人：Guizhou Bailing Group Pharmaceutical CO., LTD.

  公开号：US10227347B2

  公开（公告）日：2019-03-12

  The present invention relates to the field of the chemical medicines, and in particular, to purinyl-N-hydroxyl pyrimidine formamide derivatives, a preparation method therefor and a use thereof. The present invention provides a purinyl-N-hydroxyl pyrimidine formamide derivative having a structure represented by formula (I). The invention also provides a method for preparing said purinyl-N-hydroxyl pyrimidine formamide derivative and a use thereof. Purinyl-N-hydroxyl pyrimidine formamide derivative provided in the invention can be not only a PI3K and HDAC double-functional target kinase inhibitor, but also a PI3K or HDAC single target kinase inhibitor, thus providing new choice for preparing multi-target inhibitors.

  本发明涉及化学药物领域，尤其涉及嘌呤基-N-羟基嘧啶甲酰胺衍生物、其制备方法及其用途。本发明提供了一种嘌呤基-N-羟基嘧啶甲酰胺衍生物，其结构由式（I）表示。本发明还提供了一种制备所述嘌呤基-N-羟基嘧啶甲酰胺衍生物的方法及其用途。本发明提供的嘌呤基-N-羟基嘧啶甲酰胺衍生物不仅可以作为PI3K和HDAC双功能靶点激酶抑制剂，也可以作为PI3K或HDAC单靶点激酶抑制剂，从而为制备多靶点抑制剂提供了新的选择。
• Chiral design
  申请人：WAVE LIFE SCIENCES LTD.

  公开号：US10815482B2

  公开（公告）日：2020-10-27

  The present invention relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer.

  本发明涉及精选设计的手性控制寡核苷酸、手性控制寡核苷酸组合物以及制造和使用它们的方法。在一些实施方案中，所提供的手性控制寡核苷酸组合物提供了与参考寡核苷酸组合物不同的核酸聚合物裂解模式。在一些实施方案中，所提供的手性控制寡核苷酸组合物在核酸聚合物的互补序列内提供单位点裂解。
• Mass spectrometry of organic compounds of the group V Elements: VI—A new type of amine fragmentation under electron impact
  作者：R. G. Kostyanovsky、V. N. Voznesensky、G. K. Kadorkina、Yu. I. El'natanov

  DOI：10.1002/oms.1210150804

  日期：1980.8

  AbstractA new type of amine fragmentation under electron impact is elucidated for proline, sarcosine and aspartic acid derivatives and aminomethylphosphines of the general formula R2NCH2X. Ordinary α‐cleavage affording the \documentclassarticle}\pagestyleempty}\begindocument}$ \rm R}_2 \mathop \rm N}\limits^\rm + } \rm = CH}_\rm 2} $\enddocument} ion is suppressed by elimination of a neutral HX particle and [M ‐ HX]+ ion formation, or M‐HX neutral particle ejection and generation of an [HX]+ ion from [M]+˙. Such fragmentation is ensured by the presence of an α‐heteroatom (N, O, P, S) in one substituent (X) and a CO2R type delocalizing group in the α‐position of the other substituent (R2N).
• PURINYL-N-HYDROXYL PYRIMIDINE FORMAMIDE DERIVATIVE, PREPARATION METHODS AND USES THEREOF
  申请人：Guizhou Bailing Enterprise Group Pharmaceutical Co. Ltd.

  公开号：US20180134709A1

  公开（公告）日：2018-05-17

  The present invention relates to the field of the chemical medicines, and in particular, to purinyl-N-hydroxyl pyrimidine formamide derivatives, a preparation method therefor and a use thereof. The present invention provides a purinyl-N-hydroxyl pyrimidine formamide derivative having a structure represented by formula (I). The invention also provides a method for preparing said purinyl-N-hydroxyl pyrimidine formamide derivative and a use thereof. Purinyl-N-hydroxyl pyrimidine formamide derivative provided in the invention can be not only a PI3K and HDAC double-functional target kinase inhibitor, but also a PI3K or HDAC single target kinase inhibitor, thus providing new choice for preparing multi-target inhibitors.
• CHIRAL DESIGN
  申请人：WAVE LIFE SCIENCES LTD.

  公开号：US20190106696A1

  公开（公告）日：2019-04-11

  The present invention relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer.