Ac-D-Dmp-Arg-OMe

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Ac-D-Dmp-Arg-OMe
• 英文别名: Ac-D-Phe(2,6-diMe)-Arg-OMe；methyl (2S)-2-[[(2R)-2-acetamido-3-(2,6-dimethylphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoate
• 化学式: C₂₀H₃₁N₅O₄
• 分子量: 405.497
• InChiKey: INZGVHCWIYRXLM-DLBZAZTESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  29
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  149
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Ac-D-Dmp-Arg-OMe 在 盐酸 、 水 作用下， 反应 8.0h， 生成 2,6-二甲基-D-苯丙氨酸
  参考文献：
  名称：

  Enkephalin analogues with 2′,6′-dimethylphenylalanine replacing phenylalanine in position 4

  摘要：

  Four Leu-enkephalin (Enk) analogues containing 2'.6'-dimethyphenylalanine (Dmp) in position 4 were prepared and tested for their receptor binding and biological activities. Among the analogues prepared, [2', 6'-dimethvltyrosine(1), D-Dmp(4)]Enk was found to be an antagonist toward mu and delta opioid receptors with pA(2) values of 6.90 and 5.57, respectively. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00665-x
• 作为产物：
  描述：

  1,3-二甲基-2-碘苯 在 palladium on activated charcoal palladium diacetate 、 sodium hydroxide 、 氢气 、 1-羟基苯并三唑 、 三乙胺 、 N,N'-二环己基碳二亚胺 、 三(邻甲基苯基)磷 作用下， 以 1,4-二氧六环 、 乙酸乙酯 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 70.0 ℃ 、405.3 kPa 条件下， 反应 37.0h， 生成 Ac-D-Dmp-Arg-OMe
  参考文献：
  名称：

  Enkephalin analogues with 2′,6′-dimethylphenylalanine replacing phenylalanine in position 4

  摘要：

  Four Leu-enkephalin (Enk) analogues containing 2'.6'-dimethyphenylalanine (Dmp) in position 4 were prepared and tested for their receptor binding and biological activities. Among the analogues prepared, [2', 6'-dimethvltyrosine(1), D-Dmp(4)]Enk was found to be an antagonist toward mu and delta opioid receptors with pA(2) values of 6.90 and 5.57, respectively. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00665-x

文献信息

• Enkephalin analogues with 2′,6′-dimethylphenylalanine replacing phenylalanine in position 4
  作者：Yusuke Sasaki、Mariko Hirabuki、Akihiro Ambo、Hidekazu Ouchi、Yutaka Yamamoto

  DOI：10.1016/s0960-894x(00)00665-x

  日期：2001.2

  Four Leu-enkephalin (Enk) analogues containing 2'.6'-dimethyphenylalanine (Dmp) in position 4 were prepared and tested for their receptor binding and biological activities. Among the analogues prepared, [2', 6'-dimethvltyrosine(1), D-Dmp(4)]Enk was found to be an antagonist toward mu and delta opioid receptors with pA(2) values of 6.90 and 5.57, respectively. (C) 2001 Elsevier Science Ltd. All rights reserved.