6-(n-Butoxycarbonyloxy)-2-[4(n-butoxycarbonyloxy)phenyl]-benzo[b]thien-3-yl[4-[2-(piperidin-1-yl)ethoxy]phenyl]-methanone hydrochloride | 155861-45-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-(n-Butoxycarbonyloxy)-2-[4(n-butoxycarbonyloxy)phenyl]-benzo[b]thien-3-yl[4-[2-(piperidin-1-yl)ethoxy]phenyl]-methanone hydrochloride
• 英文别名: [2-(4-Butoxycarbonyloxyphenyl)-3-[4-(2-piperidin-1-ylethoxy)benzoyl]-1-benzothiophen-6-yl] butyl carbonate;hydrochloride
• CAS: 155861-45-3
• 化学式: C₃₈H₄₃NO₈S*ClH
• 分子量: 710.288
• InChiKey: NOQQGQZELSAIHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.72
• 重原子数：
  49
• 可旋转键数：
  19
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  129
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• Improvements in or relating to benzothiophenes
  申请人：ELI LILLY AND COMPANY

  公开号：EP0584952A1

  公开（公告）日：1994-03-02

  The current invention provides compounds, methods and pharmaceutical formulations for use in treating or preventing osteoporosis by inhibiting the loss of bone. These compounds, methods and formulations can be used without the associated adverse effects of estrogen therapy, and thus are effective in the prevention or treatment of osteoporosis.

  本发明提供了用于通过抑制骨质流失来治疗或预防骨质疏松症的化合物、方法和药物制剂。使用这些化合物、方法和制剂不会产生雌激素疗法的相关不良反应，因此可有效预防或治疗骨质疏松症。
• Benzothiophene formulations of a specific dosage
  申请人：ELI LILLY AND COMPANY

  公开号：EP0781555A1

  公开（公告）日：1997-07-02

  A pharmaceutical unit dosage form is provided, comprising from 50 to 200 mg of a benzothiophene, preferably raloxifene, or a pharmaceutically-acceptable salt thereof.

  提供了一种药物单位剂型，其中包含 50 至 200 毫克苯并噻吩，最好是雷洛昔芬，或其药学上可接受的盐。
• Methods for inhibiting bone loss
  申请人：——

  公开号：US20030212058A1

  公开（公告）日：2003-11-13

  The current invention provides methods and pharmaceutical formulations that are useful for inhibiting the loss of bone. These methods and formulations can be used without the associated adverse effects of estrogen therapy, and thus serve as an effective and acceptable treatment for osteoporosis.
• US5393763A
  申请人：——

  公开号：US5393763A

  公开（公告）日：1995-02-28
• US5457117A
  申请人：——

  公开号：US5457117A

  公开（公告）日：1995-10-10