3-(2-aminoethoxy)-5-phenylisoxazole

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(2-aminoethoxy)-5-phenylisoxazole
• 英文别名: 2-[(5-Phenyl-1,2-oxazol-3-yl)oxy]ethanamine
• 化学式: C₁₁H₁₂N₂O₂
• 分子量: 204.228
• InChiKey: QBMZBYCHYADZAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  61.3
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• ISOXAZOLE DERIVATIVES
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0885891A1

  公开（公告）日：1998-12-23

  The isoxazole derivatives having the following general formula: [wherein R1 represents an optionally substituted aryl group or aromatic heterocyclic group; R2 represents a hydrogen atom, a halogen atom, an optionally substituted alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, a cycloalkenyl group, an alkoxy group, a cyano group, a carboxyl group, an alkanoyl group, an alkoxycarbonyl group or an optionally substituted carbamoyl group; R3 represents an optionally substituted amino group or a saturated heterocyclic group; X represents an oxygen atom or a sulfur atom; n is an integer of from 2 to 6] has an excellent monoamine oxidase inhibitory activity, and is useful as a therapeutic agent or a preventive agent against nervous diseases such as depression.

  具有以下通式的异噁唑衍生物： [其中 R1 代表任选取代的芳基或芳香杂环基团；R2 代表氢原子、卤素原子、任选取代的烷基、烯基、炔基、环烷基、环烯基、烷氧基、氰基、羧基、烷酰基、烷氧羰基或任选取代的氨基甲酰基；R3 代表任选取代的氨基或饱和杂环基团；X 代表氧原子或硫原子；n 为 2 至 6 的整数]具有极佳的单胺氧化酶抑制活性，可用作治疗剂或预防剂，防治抑郁症等神经疾病。
• JPH09291082A
  申请人：——

  公开号：JPH09291082A

  公开（公告）日：1997-11-11
• JPH11139975A
  申请人：——

  公开号：JPH11139975A

  公开（公告）日：1999-05-25
• MAO-B INHIBITORS USEFUL FOR TREATING OBESITY
  申请人：McElroy Francis John

  公开号：US20070078172A1

  公开（公告）日：2007-04-05

  The invention provides a method of treating obesity, diabetes, and/or cardiometabolic disorders (e.g., hypertension, dyslipidemias, high blood pressure, and insulin resistance) in a mammal by administering to the mammal a therapeutically effective amount of an irreversible MAO-B inhibitor.
• US6005116A
  申请人：——

  公开号：US6005116A

  公开（公告）日：1999-12-21