(E)-3-(2-acetylphenyl)-N-(1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinolin-9-yl)prop-2-enamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (E)-3-(2-acetylphenyl)-N-(1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinolin-9-yl)prop-2-enamide
• 化学式: C₂₃H₂₄N₂O₂
• 分子量: 360.4
• InChiKey: MLSUQXSNPNEVGI-PKNBQFBNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] CONDENSED TRICYCLIC PIPERIDINES HAVING ANTI-CONVULSANT ACTIVITY<br/>[FR] PIPERIDINES TRICYCLIQUES CONDENSEES A ACTION ANTI-CONVULSIVE
  申请人：SMITHKLINE BEECHAM PLC

  公开号：WO2000008023A1

  公开（公告）日：2000-02-17

  Compounds of formula (I) or salts thereof or solvates thereof in which: X is CH or N; P is -CH=CH- and Q is -NR6-, or; P is -CH=CH- and Q is -NR6CH2-, or; P is -NH- and Q is -CR?3=CH-; R6¿ is hydrogen, phenylC¿1-6?alkyl, or C1-6alkyl; R?3¿ is hydrogen, halo, phenylC¿1-6?alkyl, or C1-6alkyl; A is a monocyclic aromatic carbocyclic or heterocyclic compound or a bicyclic carbocyclic or heterocyclic compound in which one ring is aromatic; m is 1 or 2; n is 1 or 2; R?1¿ is hydrogen or up to two substituents selected from fluoro or C¿1-6?alkyl; R?2¿ is hydrogen or up to four substituents selected from halogen, NO¿2?, CN, N3, CF3O-, CF3S-, CF3CO-, trifluoromethyldiazirinyl, C1-6alkyl, C1-6alkenyl, C1-6alkynyl, C1-6perfluoroalkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl-, C1-6alkylO-, C1-6alkylCO-, C3-6cycloalkylO-, C3-6cycloalkylCO-, C3-6cycloalkyl-C1-4alkylO-, C3-6cycloalkyl-C1-4alkylCO-, phenyl, phenoxy, benzyloxy, benzoyl, phenyl-C1-4alkyl-, C1-6alkylS-, C1-6alkylSO2-, (C1-4alkyl)2NSO2-, (C1-4alkyl)NHSO2-, (C1-4alkyl)2NCO-, oxazolyl, (C1-4alkyl)NHCO- or CONH2; or -NR?4R5¿ or -NHCOR 4 where R4 is hydrogen or C¿1-4?alkyl, and; R?5¿ is hydrogen, C¿1-4?alkyl, formyl, -CO2C1-4alkyl or -COC1-4alkyl; or two R?2¿ groups are linked together to form a carbocyclic or heterocyclic ring that is saturated or unsaturated and unsubsituted or substituted by -OH or =O; R3 is hydrogen, halogen, phenylC¿1-6?alkyl, or C1-6alkyl; or R?3¿ and R¿2? are linked together form a saturated or unsaturated carbocyclic or heterocyclic ring are indicated to be useful in the treatment and prophylaxis of epilepsy, migraine, and other disorders.