5-(4-Aminophenoxy)-1,3-dihydroindol-2-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-(4-Aminophenoxy)-1,3-dihydroindol-2-one
• 化学式: C₁₄H₁₂N₂O₂
• 分子量: 240.26
• InChiKey: LJQDJKMHWJKUHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Indolone derivatives having vascular damaging activity
  申请人：——

  公开号：US20040147589A1

  公开（公告）日：2004-07-29

  This invention relates to the use of compounds of Formula (I) as vascular damaging agents: wherein X is selected from: —O—, —S—, —S(O)—, —S(O 2 )—, —N(R 5 )—, —C(O)—, —C(O)N(R 5 )—, —N(R 5 )C(O)—, —S(O2)N(R 5 )—, or —N(R 5 )S(O 2 )—; R 1 is independently selected from: amino, halo, hydroxy, —OPO 3 H 2 , C 1-4 alkyl, or C 1-4 alkoxy, wherein the amino group is optionally substituted by an amino acid residue and the hydroxy group is optionally esterified; R 2 is selected from: hydrogen or C 1-4 alkyl; R 3 is selected from: hydrogen, halo, hydroxy, hydroxyC 1-4 alkyl, cyano, cyanoC 1-4 alkyl, carboxy, carboxyC 1-4 alkyl, C 1-4 alkanoyl, C 1-4 alkanoylC 1-4 alkyl, carbamoyl, carbamoylC 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkoxycarbonyl, C 1-4 alkoxycarbonylC 1-4 alkyl, C 1-4 alkoxycarbonylamino, amino, N-C 1-4 alkylamino, NN-diC 1-4 alkylamino, aminoC 1-4 alkyl, N-C 1-4 alkylaminoC 1-4 alkyl, NN-diC 1-4 alkylaminoC 1-4 alkyl, ureido, or C 1-4 alkylureyleno; R 4 is independently selected from: C 1-4 alkyl, C 1-4 alkoxy or halo; R 5 is selected from: hydrogen or C 1-4 alkyl; n is 0 or 1; p is 0, 1, 2 or 3; and q is 0, 1 or 2; or a salt, pro-drug or solvate thereof. The invention also relates to novel compounds of Formula (I) and to processes for the preparation of compounds of Formula (I). 1

  本发明涉及使用式（I）化合物作为血管损伤剂的方法：其中X选择自：—O—，—S—，—S（O）—，—S（O2）—，—N（R5）—，—C（O）—，—C（O）N（R5）—，—N（R5）C（O）—，—S（O2）N（R5）—或—N（R5）S（O2）—；R1独立选择自：氨基，卤素，羟基，—OPO3H2，C1-4烷基或C1-4烷氧基，其中氨基团可以选择性地被氨基酸残基取代，羟基可以选择性地酯化；R2选择自：氢或C1-4烷基；R3选择自：氢，卤素，羟基，羟基C1-4烷基，氰基，氰基C1-4烷基，羧基，羧基C1-4烷基，C1-4酰基，C1-4酰基C1-4烷基，氨基甲酰基，氨基甲酰基C1-4烷基，C1-4烷氧基，C1-4烷氧羰基，C1-4烷氧羰基C1-4烷基，C1-4烷氧羰基氨基，氨基，N-C1-4烷基氨基，NN-二C1-4烷基氨基，氨基C1-4烷基，N-C1-4烷基氨基C1-4烷基，NN-二C1-4烷基氨基C1-4烷基，脲基或C1-4烷基脲基；R4独立选择自：C1-4烷基，C1-4烷氧基或卤素；R5选择自：氢或C1-4烷基；n为0或1；p为0、1、2或3；q为0、1或2；或其盐、前药或溶剂。本发明还涉及式（I）的新化合物以及制备式（I）化合物的方法。
• INDOLONE DERIVATIVES HAVING VASCULAR-DAMAGING ACTIVITY
  申请人：AstraZeneca AB

  公开号：EP1370527A1

  公开（公告）日：2003-12-17
• US7186745B2
  申请人：——

  公开号：US7186745B2

  公开（公告）日：2007-03-06
• [EN] INDOLONE DERIVATIVES HAVING VASCULAR-DAMAGING ACTIVITY<br/>[FR] DÉRIVÉS INDOLONE CAPABLE DE DÉGRADER DES VAISSEAUX
  申请人：ASTRAZENECA AB

  公开号：WO2002070478A1

  公开（公告）日：2002-09-12

  This invention relates to the use of compounds of Formula (I) as vascular damaging agents: wherein X is selected from: -O-, -S-, -S(O)-, -S(O2)-, -N(R5)-, -C(O)-, -C(O)N(R5)-, -N(R5)C(O)-, -S(O2)N(R5)-, or -N(R5)S(O2)-; R1 is independently selected from: amino, halo, hydroxy, -OPO3H2, C1-4alkyl, or C1-4alkoxy, wherein the amino group is optionally substituted by an amino acid residue and the hydroxy group is optionally esterified; R2 is selected from: hydrogen or C1-4alkyl; R3 is selected from: hydrogen, halo, hydroxy, hydroxyC1-4alkyl, cyano, cyanoC1-4alkyl, carboxy, carboxyC1-4alkyl, C1-4alkanoyl, C1-4alkanoylC1-4alkyl, carbamoyl, carbamoylC1-4alkyl, C1-4alkoxy, C1-4alkoxycarbonyl, C1-4alkoxycarbonylC1-4alkyl, C1-4alkoxycarbonylamino, amino, N-C1-4alkylamino, NN-diC1-4alkylamino, aminoC1-4alkyl, N-C1-4alkylaminoC1-4alkyl, NN-diC1-4alkylaminoC1-4alkyl, ureido, or C1-4alkylureyleno; R4 is independently selected from: C1-4alkyl, C1-4alkoxy or halo; R5 is selected from: hydrogen or C1-4alkyl; n is 0 or 1; p is 0, 1, 2 or 3; and q is 0,1 or 2; or a salt, pro-drug or solvate thereof. The invention also relates to novel compounds of Formula (I) and to processes for the preparation of compounds of Formula (I).