2-[5-(2-Hydroxyethyl)-4-methyl-1,3-thiazol-3-ium-3-yl]acetonitrile;bromide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-[5-(2-Hydroxyethyl)-4-methyl-1,3-thiazol-3-ium-3-yl]acetonitrile;bromide
• 化学式: C8H11BrN2OS
• 分子量: 263.16
• InChiKey: MZVHWEKLNVMSSP-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.59
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  76.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Method for treating fibrotic diseases or other indications IC
  申请人：Alteon, Inc.

  公开号：US20020068729A1

  公开（公告）日：2002-06-06

  Provided, among other things, is a method of treating or ameliorating or preventing an indication of the invention in an animal, including a human comprising administering an effective amount of a compound of the formula I: 1

  提供了一种处理、改善或预防动物包括人类发明的指示的方法，包括给予公式I的化合物的有效量：1
• Method for treating fibrotic diseases or other indications ID
  申请人：——

  公开号：US20020177586A1

  公开（公告）日：2002-11-28

  Provided, among other things, is a method of treating or ameliorating or preventing an indication of the invention in an animal, including a human comprising administering an effective amount of a compound of the formula I: 1

  提供了一种在动物中（包括人类）治疗、改善或预防本发明指示的方法，其中包括给予化合物I的有效量：1。
• Method for treating fibrotic diseases or other indications IE
  申请人：——

  公开号：US20040235837A1

  公开（公告）日：2004-11-25

  Provided, among other things, is a method of treating or ameliorating or preventing an indication of the invention in an animal, including a human comprising administering an effective amount of a compound of the formula I: 1

  提供了一种治疗、改善或预防发明所示迹象的方法，在动物中包括人类，该方法包括给予化合物I的有效剂量：1。
• Method for treating glaucoma IC
  申请人：——

  公开号：US20020160993A1

  公开（公告）日：2002-10-31

  Provided is a method of treating or ameliorating or preventing glaucoma, decreasing intraocular pressure or improving or amemliorting ocular accommodation in an animal, including a human comprising administering an intraocular pressure decreasing or accommodation improving amount of a compound of the formula I: 1

  提供了一种治疗、改善或预防青光眼、降低眼压或改善或缓解动眼调节的方法，包括在动物（包括人类）中给予化合物I的降低眼压或改善动眼调节的剂量。
• Method for treating diabetic nephropathy
  申请人：Egan John

  公开号：US20090124673A1

  公开（公告）日：2009-05-14

  Provided, among other things, is a method of treating or ameliorating or preventing an indication of the invention in an animal, including a human comprising administering an effective amount of a compound of the formula I:

  提供的是一种治疗、改善或预防本发明适应症的动物，包括人类的方法，其中包括给予化合物I的有效剂量。