3-(2-(2-pyridinyl)-2-oxoethyl)-4,5-dimethyl-thiazolium bromide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(2-(2-pyridinyl)-2-oxoethyl)-4,5-dimethyl-thiazolium bromide
• 英文别名: 2-(4,5-Dimethyl-1,3-thiazol-3-ium-3-yl)-1-pyridin-2-ylethanone;bromide
• 化学式: Br*C₁₂H₁₃N₂OS
• 分子量: 313.218
• InChiKey: ZQGZYARQBGFRNE-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.07
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  62.1
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Method for treating fibrotic diseases or other indications IC
  申请人：Alteon, Inc.

  公开号：US20020068729A1

  公开（公告）日：2002-06-06

  Provided, among other things, is a method of treating or ameliorating or preventing an indication of the invention in an animal, including a human comprising administering an effective amount of a compound of the formula I: 1

  提供了一种处理、改善或预防动物包括人类发明的指示的方法，包括给予公式I的化合物的有效量：1
• Method for treating fibrotic diseases or other indications ID
  申请人：——

  公开号：US20020177586A1

  公开（公告）日：2002-11-28

  Provided, among other things, is a method of treating or ameliorating or preventing an indication of the invention in an animal, including a human comprising administering an effective amount of a compound of the formula I: 1

  提供了一种在动物中（包括人类）治疗、改善或预防本发明指示的方法，其中包括给予化合物I的有效量：1。
• Reversing advanced glycosylation cross-links using heterocyclic-substituted thiazolium compounds
  申请人：——

  公开号：US20030176417A1

  公开（公告）日：2003-09-18

  The present invention relates to compositions and methods for reversing advanced glycosylation end product-mediated cross-linking and protein aging. Accordingly, compositions are described which comprise thiazolium compounds substituted with heterocyclic groups which are capable of reversing the formation of advanced glycosylation end product cross-links. Both industrial and therapeutic applications for the invention are disclosed, as food spoilage and animal protein aging can be treated. Such compounds have particular application in the treatment of protein aging such as is responsible for the complications of aging and diabetes.

  本发明涉及用于逆转高级糖基化终产物介导的交联和蛋白质老化的组合物和方法。因此，本发明描述了含有被杂环基取代的噻唑化合物的组合物，这些化合物能够逆转高级糖基化终产物交联的形成。本发明揭示了该发明的工业和治疗应用，因为食品变质和动物蛋白质老化可以得到治疗。这些化合物在治疗蛋白质老化方面具有特殊应用，如对与衰老和糖尿病并发症有关的蛋白质老化的治疗。
• Method for treating fibrotic diseases or other indications IE
  申请人：——

  公开号：US20040235837A1

  公开（公告）日：2004-11-25

  Provided, among other things, is a method of treating or ameliorating or preventing an indication of the invention in an animal, including a human comprising administering an effective amount of a compound of the formula I: 1

  提供了一种治疗、改善或预防发明所示迹象的方法，在动物中包括人类，该方法包括给予化合物I的有效剂量：1。
• Reversing advanced glycosylation cross-links using heterocyclic-substituted thiazolium salts
  申请人：——

  公开号：US20020160992A1

  公开（公告）日：2002-10-31

  The present invention relates to compositions and methods for reversing advanced glycosylation end product-mediated cross-linking and protein aging. Accordingly, compositions are described which comprise thiazolium compounds substituted with heterocyclic groups which are capable of reversing the formation of advanced glycosylation end product cross-links. Both industrial and therapeutic applications for the invention are disclosed, as food spoilage and animal protein aging can be treated. Such compounds have particular application in the treatment of protein aging such as is responsible for the complications of aging and diabetes.

  本发明涉及用于逆转高级糖基化产物介导的交联和蛋白质老化的组合物和方法。因此，本发明描述了含有异杂环基取代的噻唑化合物的组合物，其能够逆转高级糖基化产物交联的形成。本发明揭示了工业和治疗应用，因为可以处理食品变质和动物蛋白质老化。这些化合物在治疗蛋白质老化方面具有特殊应用，例如对于导致衰老和糖尿病并发症的蛋白质老化。