(2R,3S,4R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-2-methyloxolane-3,4-diol

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: (2R,3S,4R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-2-methyloxolane-3,4-diol
• 化学式: C₁₁H₁₅N₅O₄
• 分子量: 281.27
• InChiKey: ZYRABNSYSYDHMR-FHAWUSBBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  140
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• 1'-, 2'- AND 3' -MODIFIED NUCLEOSIDE DERIVATIVES FOR TREATING FLAVIVIRIDAE INFECTIONS
  申请人：Idenix (Cayman) Limited

  公开号：EP1525209A2

  公开（公告）日：2005-04-27
• [EN] 2' AND 3'-NUCLEOSIDE PRODRUGS FOR TREATING FLAVIVIRIDAE INFECTIONS<br/>[FR] PROMEDICAMENTS 2' ET 3' DE NUCLEOSIDE PERMETTANT DE TRAITER DES INFECTIONS PAR LES FLAVIVIRIDAE
  申请人：IDENIX CAYMAN LTD

  公开号：WO2004003000A2

  公开（公告）日：2004-01-08

  2' and 3'-Prodrugs of l', 2', 3' or 4'-branched ß-D or ß-L nucleosides, or their pharmaceutically acceptable salts and derivatives are described, which are useful in the prevention and treatment of Flaviviridae infections and other related conditions. These modified nucleosides provide superior results against flaviviruses and pestiviruses, including hepatitis C virus and viruses generally that replicate through an RNA dependent RNA reverse transcriptase. Compounds, compositions, methods and uses are provided for the treatment of Flaviviridae infection, including HCV infection, that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.