2-[(3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]ethyl 2-methylprop-2-enoate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-[(3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]ethyl 2-methylprop-2-enoate
• 化学式: C₁₂H₂₀O₇
• 分子量: 276.28
• InChiKey: KRHQAZUXZCJPFY-OXKBGPBOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  116
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• NOVEL SUGAR DERIVATIVE GELATORS
  申请人：KYUSHU UNIVERSITY

  公开号：US20180208618A1

  公开（公告）日：2018-07-26

  A novel gelator including a sugar derivative; a gelator including a compound of Formula (1) or Formula (2): wherein R 1 is a linear or branched alkyl group having a carbon atom number of 9 to 20, a cyclic alkyl group having a carbon atom number of 13 to 20, or a linear or branched alkenyl group having a carbon atom number of 9 to 20, R 2 is a hydrogen atom, a linear or branched alkyl group having a carbon atom number of 1 to 10, or an aryl group optionally having a substituent, and R 3 and R 4 are hydroxy groups.

  一种包括糖衍生物的新型凝胶剂；一种包括化合物Formula（1）或Formula（2）的凝胶剂：其中，R1是具有碳原子数为9至20的直链或支链烷基基团，具有碳原子数为13至20的环烷基基团，或具有碳原子数为9至20的直链或支链烯基基团，R2是氢原子，具有碳原子数为1至10的直链或支链烷基基团，或具有取代基的芳基基团，而R3和R4是羟基。
• Antibacterial, antifungal compound and its production method
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0599265A1

  公开（公告）日：1994-06-01

  A compound represented by the following formula: wherein R is an acyl group which may or not be substituted. R¹ is a hydrogen atom, C₁₋₁₀ hydrocarbon group which may or may not be substituted, or an acyl group which may or may not be substituted, R² is a straight chain or branched C₁₋₁₂ alkylene group which may or may not be substituted, A is a straight chain or branched C₁₋₁₀ alkylene group, B is O, NH or S, Q is a tertiary amino or quaternary ammonium group, a nitrogen-containing heterocyclic group which may or may not be substituted, or a nitrogen-containing heterocyclic ammonium group which may or may not be substituted, and n is an integer from 1 to 10, and the method of manufacturing this compound.

  以下化合物的化学式：其中R是一个酰基，可以是取代或非取代的。R¹是氢原子，C₁₋₁₀烃基，可以是取代或非取代的酰基，R²是直链或支链的C₁₋₁₂烷基，可以是取代或非取代的，A是直链或支链的C₁₋₁₀烷基，B是O，NH或S，Q是三级胺或季铵基，一种含氮杂环基团，可以是取代或非取代的，或者一种含氮杂环铵基团，可以是取代或非取代的，n是1到10的整数。以及制造该化合物的方法。
• STICK-SHAPED BASE MATERIAL COMPRISING LIPID PEPTIDE COMPOUND
  申请人：NISSAN CHEMICAL INDUSTRIES, LTD.

  公开号：US20180200173A1

  公开（公告）日：2018-07-19

  A solid base material for external use on skin that has a breaking strength sufficiently high to be usable as a stick-shaped base material or the like. A solid base material for external use on skin containing a lipid peptide compound including at least one of compound of Formula (1), the similar compound thereof and the pharmacologically usable salts thereof; water; and a 1,3-alkanediol; wherein R 1 is a C 9-23 aliphatic group; R 2 is a hydrogen atom or a C 1-4 alkyl group optionally having a C 1 or C 2 branched chain; and R 3 is a —(CH 2 ) n —X group, wherein n is a number from 1 to 4, and X is amino group, guanidino group, -CONH 2 group, or a 5-membered ring group or 6-membered ring group optionally having one to three nitrogen atoms or a fused heterocyclic group composed of the 5-membered ring and the 6-membered ring.

  一种用于外用于皮肤的固体基材料，其断裂强度足够高，可用作棒状基材料或类似物。一种用于外用于皮肤的固体基材料，包含一个脂肽化合物，其中至少包括公式（1）的化合物、类似的化合物及其药学可用的盐；水；和1,3-烷二醇；其中R1是C9-23脂肪基；R2是氢原子或C1-4烷基，可选地具有C1或C2支链；R3是—（CH2）n—X基团，其中n是1至4之间的数字，而X是氨基、鸟氨酸基、-CONH2基团或具有1至3个氮原子或由5-成员环和6-成员环组成的融合杂环基团中的5-成员环基团或6-成员环基团。
• STICK-SHAPED BASE MATERIAL CONTAINING LIPID PEPTIDE COMPOUND
  申请人：NISSAN CHEMICAL INDUSTRIES, LTD.

  公开号：US20160324749A1

  公开（公告）日：2016-11-10

  A solid base material for skin external application has a breaking strength high enough to be used for a stick-shaped base material and the like. A solid base material for skin external application has: a surfactant; water; and a lipid peptide compound including at least one of compounds of Formula (1) and the analogous thereof or pharmaceutically usable salts of the compound: wherein R 1 is a C 9-23 aliphatic group; R 2 is a hydrogen atom, or a C 1-4 alkyl group that may have a C 1 or C 2 branched chain; R 3 is a —(CH 2 ) n —X group, where n is a number from 1 to 4, and X is amino group, guanidino group, —CONH 2 group, or a 5-membered or 6-membered ring that may have 1 to 3 nitrogen atoms or a condensed heterocycle composed of 5-membered and 6-membered rings that may have 1 to 3 nitrogen atoms.

  一种适用于皮肤外用的固态基材料具有足够高的断裂强度，可用于棒状基材料等。一种适用于皮肤外用的固态基材料包括：表面活性剂；水；以及包括以下化合物之一或其类似物或药用可用盐的脂肽化合物：其中R1是C9-23脂肪基；R2是氢原子或C1-4烷基，可以具有C1或C2支链；R3是—（CH2）n—X基团，其中n是1到4的数字，X是氨基团，鸟氨酸基团，—CONH2基团，或者是一个具有1到3个氮原子的5元或6元环，或者是由5元和6元环组成的具有1到3个氮原子的缩合杂环。
• STICK-SHAPED BASE MATERIAL HAVING HIGH WATER CONTENT
  申请人：NISSAN CHEMICAL CORPORATION

  公开号：US20200197284A1

  公开（公告）日：2020-06-25

  A stick-shaped base material capable of having a breaking strength required for a stick-shaped base material even when the amount of a lipid peptide compound contained therein is reduced, including: a surfactant; water; a lipid peptide compound including at least one of compound of the following Formula (1) and similar compound thereof or pharmaceutically usable salts of the compounds: wherein R 1 is a C 9-23 aliphatic group; R 2 is a hydrogen atom or a C 1-4 alkyl group optionally having a C 1 or C 2 branched chain; and R 3 is a —(CH 2 ) n —X group, wherein n is a number of 1 to 4, and X is an amino group, guanidine group, or a —CONH 2 group, or a 5-membered or 6-membered ring optionally having one to three nitrogen atoms or a fused heterocyclic ring composed of the rings; a 1,2-alkanediol or a 1,3-alkanediol; at least one fatty acid; and an alginic acid derivative.

  一种棒状基材料，即使其中含有脂肽化合物的量减少，仍能具有棒状基材料所需的断裂强度，包括：表面活性剂；水；脂肽化合物，其中包括以下式（1）的化合物和类似化合物或其药用盐之一：其中R1是C9-23脂肪基；R2是氢原子或C1-4烷基，可选地具有C1或C2支链；R3是—（CH2）n—X基团，其中n为1至4的数字，X是氨基、鸟氨酸基或—CONH2基团，或者是具有1至3个氮原子的5元或6元环，或者是由这些环组成的融合杂环；1,2-癸二醇或1,3-癸二醇；至少一种脂肪酸；和藻酸衍生物。