(10E)-cycloicos-10-en-1-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (10E)-cycloicos-10-en-1-one
• 化学式: C₂₀H₃₆O
• 分子量: 292.5
• InChiKey: WEVQMNKNYVHCIM-OWOJBTEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] IMPROVED IMAGING AGENTS COMPRISING BARBITURIC ACID DERIVATIVES<br/>[FR] AGENTS D'IMAGERIE AMELIORES CONTENANT DES DERIVES DE L'ACIDE BARBITURIQUE
  申请人：AMERSHAM PLC

  公开号：WO2004032936A1

  公开（公告）日：2004-04-22

  The present invention relates to diagnostic imaging agents for in vivo imaging. The imaging agents comprise a synthetic barbituric acid derivative labelled at the 5-position with an imaging moiety suitable for diagnostic imaging in vivo. The invention also provides pharmaceutical and radiopharmaceutical compositions comprising the imaging agents, together with kits of the preparation of the radiopharmaceuticals. Also described are chelator conjugates of the barbituric acid derivative, which are suitable for the preparation of imaging agents comprising a radioactive or paramagnetic metal ion. The imaging agents are useful for the diagnostic imaging in vivo of various disease states, including atherosclerosis.

  本发明涉及用于体内成像的诊断成像剂。成像剂包括一种合成的巴比妥酸衍生物，在5位标记有适用于体内诊断成像的成像基团。本发明还提供了包括成像剂的制药和放射药物组合物，以及放射药物的制备套件。此外，还描述了巴比妥酸衍生物的螯合物共轭物，适用于制备包含放射性或顺磁性金属离子的成像剂。成像剂对于体内各种疾病状态的诊断成像非常有用，包括动脉粥样硬化。
• Melanin production inhibitors and skincare products containing such inhibitors
  申请人：——

  公开号：US20030049213A1

  公开（公告）日：2003-03-13

  A melanin synthesis inhibitor composition containing at least one macrocyclic compound represented by Formula (1) 1 wherein X is a group selected among the groups consisting of C═O; CH—OH and O═C—CHOH; R being a chain hydrocarbon having 13 to 24 carbon atoms, R forms a ring with X and may be saturated or contain 1 to 3 unsaturated bonds and may be substituted by a lower alkyl group of 1 to 3 carbon atoms.

  一种含有至少一种由式（1）表示的大环化合物的黑色素合成抑制剂组合物，其中X是从C═O、CH—OH和O═C—CHOH组成的群体中选择的一种，R是具有13至24个碳原子的链烃，R与X形成环，可以是饱和的或含有1至3个不饱和键，并且可以被1至3个碳原子的低级烷基取代。
• IMPROVED IMAGING AGENTS COMPRISING BARBITURIC ACID DERIVATIVES
  申请人：GE Healthcare Limited

  公开号：EP1549317A1

  公开（公告）日：2005-07-06
• TOPICAL COMPOSITIONS AND METHODS FOR WHITENING SKIN
  申请人：ELC Management LLC

  公开号：EP2254546A2

  公开（公告）日：2010-12-01
• Skin whitening compositions based on hydroxyaryl alkyl ketones and their isosteric derivatives
  申请人：Gupta K. Shyam

  公开号：US20050271608A1

  公开（公告）日：2005-12-08

  I have discovered that certain hydroxyaryl or polyhydroxyaryl compounds that contain an alkyl carbon side chain with a hetero-atom group attached by a double bond at the first carbon atom of the alkyl side chain that is directly attached to the aromatic ring, as illustrated in FIG. 1 , provide a surprising and unexpected skin whitening effect. The addition of metal ions, such as copper, zinc, selenium, or vanadium and certain antioxidant compositions additionally increases the skin whitening effect.