1-N',3-N'-bis(cyclopropanecarbothioyl)-1-N',3-N'-diethylpropanedihydrazide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-N',3-N'-bis(cyclopropanecarbothioyl)-1-N',3-N'-diethylpropanedihydrazide
• 化学式: C₁₅H₂₄N₄O₂S₂
• 分子量: 356.5
• InChiKey: VHLSFGNCMFGQHP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  129
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Paclitaxel enhancer compound
  申请人：Koya Keizo

  公开号：US20080242702A1

  公开（公告）日：2008-10-02

  One embodiment of the present invention is a compound represented by the Structural Formula (I): Y is a covalent bond of a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken together with both >C=Z groups to which it is bonded, is a substituted or unsubstituted aromatic group. Preferably, Y is a covalent bond or —C(R 7 R 8 )—. R 1 is an aliphatic group, a substituted aliphatic group, a non-aromatic heterocyclic group, or a substituted non-aromatic heterocyclic group, R 2 -R 4 are independently —H, an aliphatic group, a substituted aliphatic group, a non-aromatic heterocyclic group, a substituted non-aromatic heterocyclic group, an aryl group or a substituted aryl group, or R 1 and R 3 taken together with the carbon and nitrogen atoms to which they are bonded, and/or R 2 and R 4 taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. R 5 -R 6 are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. R 7 and R 8 are each independently —H, an aliphatic or substituted aliphatic group, or R 7 is —H and R 8 is a substituted or unsubstituted aryl group, or, R 7 and R 8 , taken together, are a C2-C6 substituted or unsubstituted alkylene group. Z is ═O or ═S. Also disclosed are pharmaceutical compositions comprising the compound of the present invention and a pharmaceutically acceptable carrier or diluent.
• US7368473B2
  申请人：——

  公开号：US7368473B2

  公开（公告）日：2008-05-06
• US7750042B2
  申请人：——

  公开号：US7750042B2

  公开（公告）日：2010-07-06
• US7763658B2
  申请人：——

  公开号：US7763658B2

  公开（公告）日：2010-07-27